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Holly A. LaVoie
Has grant
Professor
United StatesResearch Interests
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Recent Grants
Grant: Close
South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE)
Open Date: 2001-09-30
Close Date: 2026-08-31
Articles (4)
Year:
2026
Year:
2026
Year:
2025
Pregnancy and lactation increase volume load on the heart. Defects in cardiac remodeling during pregnancy and postpartum can result in peripartum cardiomyopathy. TIMPs participate in cardiac remodeling. The present study reports the cardiac function in Timp4 knockout adult female mice during pregnancy and lactation. Timp4 knockout females at many time points have higher ejection fraction to maintain stroke volume. Global deletion of Timp4 was not detrimental to maternal heart function during first pregnancies and lactation.
Year:
2023
Collaborators (2)
Natalie J Hannan
C R Roper Fellow (Senior Scientist)
University of Melbourne
Francis Spinale
Medical University of South Carolina
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