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Hoseah Akala

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Principal Research Scientist/ Director, Malaria Drug Resistance Program

Kenya Medical Research Institute

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Research Interests

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Professors in Pharmaceutical Chemistry

Recent Grants

Grant: Close

Epidemiology of malaria drug resistance patterns in Kenya

Open Date: 2023-10-01

Close Date: 2025-10-01

Grant: Close

IN SILICO PRIORITIZATION OF COMPOUNDS FROM OPEN SOURCE RE:FRAME LIBRARY

Open Date: 2020-01-01

Close Date: 2022-01-01

Articles (20)

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Collaborators (6)

Mirjam Groger

Bernhard Nocht Institute for Tropical Medicine

GERMANY

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Reagan Mogire

Open University

UNITED KINGDOM

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Nicolas Argy

associate professor

Université Paris Cité

FRANCE

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Anne Debourgogne

Professor

University Hospital of Nancy

FRANCE

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Michael Ramharter

Professor

Bernhard-Nocht-Institut für Tropenmedizin

GERMANY

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Erick M.O. Muok

Director

Kenya Medical Research Institute

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Hoseah Akala

Research Interests

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Recent Grants

Articles (20)

Spatial surveillance of Plasmodium falciparum Kelch 13 mutations reveals High-Frequency A675V and the First Molecular Evidence of Suspected Partial Artemisinin Resistance in Baringo in Kenya

Low prevalence of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions in archived samples collected before and after nationwide malaria-RDT rollout in Kenya

Antiplasmodial Compounds from<i> Clerodendrum</i><i> rotundifolium</i> Oliv. and Oral Toxicity Assessment of the Leaf Extracts

Antiplasmodial activity, phytochemical analysis and in silico study of the leaf extract of <i>Chenopodium opulifolium</i> Koch & Ziz used in Uganda

Evolving patterns of antimalarial drug resistance markers in symptomatic infections in Kenya, 2013-2022

Antimalarial Drug Repurposing of Epirubicin and Pelitinib in Combination with Artemether and Lumefantrine

Malaria Chemotherapeutics What Next for Africa

<i>In vitro</i>, <i>ex vivo,</i> and <i>in silico</i> studies of phytochemicals from the stem bark of <i>Bischofia javanica</i>

Consistency and reproducibility of independent feedings using blood from two consecutive days at varying <i>Plasmodium falciparum</i> gametocyte densities based on both direct membrane feeding assay and direct skin feeding assay

Convenient screening for drug resistance mutations from historical febrile malaria samples across Kenya

Efficacy of RTS,S/AS01<sub>E</sub> Only Seen in Baseline Parasitemic and Not Baseline Aparasitemic Plasmodium falciparum-Exposed, Drug-Treated Kenyan Adults

Global assessment of partial artemisinin resistance: multicenter trial across Kenya, Peru, and Thailand in patients with uncomplicated Plasmodium falciparum malaria

MLDockKit: A precision drug discovery platform for prostate cancer

Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study.

Protein target similarity is positive predictor of in vitro antipathogenic activity: a drug repurposing strategy for Plasmodium falciparum.

The Walter Reed Project, Kisumu Field Station: Impact of Research on Malaria Policy, Management, and Prevention.

Antiviral Rotenoids and Isoflavones Isolated from <i>Millettia</i> <i>oblata</i> ssp. <i>teitensis</i>.

Increased sensitivity of malaria parasites to common antimalaria drugs after the introduction of artemether-lumefantrine: Implication of policy change and implementation of more effective drugs in fight against malaria

Comparative analysis of peripheral whole blood transcriptome from asymptomatic carriers reveals upregulation of subsets of surface proteins implicated in <i>Plasmodium falciparum</i> phenotypic plasticity.

Implications of asymptomatic malaria infections on hematological parameters in adults living with HIV in malaria endemic regions with varying transmission intensities.

Collaborators (6)

Mirjam Groger

Reagan Mogire

Nicolas Argy

Anne Debourgogne

Michael Ramharter

Erick M.O. Muok

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