Hou-Fu Guo

Assistant Professor

University of Kentucky

United States

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Dr. Hou-Fu Guo is an Assistant Professor at the University of Kentucky, USA. His research primarily focuses on collagen glycosyltransferases and the structural biology of mimiviruses, exploring their implications in areas such as cancer biology and enzyme inhibition. His recent publications include investigations into the functional roles of lysyl hydroxylase and galactosyltransferases in disease contexts.

Articles (14)

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2025

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2025

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2025

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2023

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2022

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2021

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2021

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2021

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2020

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2020

Collaborators (8)

Mitchell Miller

Rice University

UNITED STATES

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Roma Stawikowska

Florida Atlantic University

UNITED STATES

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Pengyu Ren

Professor

University of Texas at Austin

UNITED STATES

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Chi-Lin Tsai

Assistant Professor

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Jeramiah Smith

Associate Professor

University of Kentucky

UNITED STATES

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Don L. Gibbons

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Bo Liang

Associate Professor

Emory University School of Medicine

UNITED STATES

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Lei Shi

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Hou-Fu Guo

Research Interests

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Articles (14)

The Crystal Structure of Acanthamoeba Polyphaga Mimivirus R655 and Its Potential Glycosaminoglycan Glycosyltransferase Activity

Structure of an Fe2+-binding-deficient mimiviral collagen lysyl hydroxylase

Cloning, expression, and characterization of collagen galactosyltransferases from human, sponge, and sea walnut

Computational Investigation of a Series of Small Molecules as Potential Compounds for Lysyl Hydroxylase-2 (LH2) Inhibition

Unleashing the Potential of 1,3-Diketone Analogues as Selective LH2 Inhibitors

Comparative genomic and biochemical analyses identify a collagen galactosylhydroxylysyl glucosyltransferase from Acanthamoeba polyphaga mimivirus.

Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes

Novel Expansion of Matrix Metalloproteases in the Laboratory Axolotl (Ambystoma mexicanum) and Other Salamander Species

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.

A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma

The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells

Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity

PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma

Erratum: PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma (Science Translational Medicine DOI: 10.1016/j.bbcan.2016.06.002)

Collaborators (8)

Mitchell Miller

Roma Stawikowska

Pengyu Ren

Chi-Lin Tsai

Jeramiah Smith

Don L. Gibbons

Bo Liang

Lei Shi

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