Howard Y. Chang
Stanford University School of Medicine
United StatesResearch Interests
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Articles (1)
Summary: Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs—local congregations of ecDNAs in the nucleus—highlight unique features of ecDNA biology that may contribute to higher oncogene expression and rapid tumor evolution.
Year:
2022
Collaborators (1)
Natasha Weiser
Stanford University
UNITED STATES
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