Hu Zeng

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Senior Associate Consultant I/Assistant Professor

Mayo Clinic Rochester

United States

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About

Hu Zeng is a Senior Associate Consultant I and Assistant Professor at Mayo Clinic Rochester, USA. His research focuses on the immune system, particularly in the areas of B cell metabolism, T cell responses, and systemic autoimmunity, as evidenced by his recent publications. Notable topics include the nutrient-sensing mechanisms in B cells, the role of fatty acid metabolism in immunity, and the effects of immunotherapies in various disease contexts.

Recent Grants

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Targeting mTORC2 for lupus treatment

Open Date: 2020-10-01

Close Date: 2022-09-30

Articles (16)

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Collaborators (2)

Whitney Barham

Vanderbilt University

UNITED STATES

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Ayesha Saleem

Associate Professor (tenure-track)

University of Manitoba

CANADA

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Hu Zeng

Research Interests

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About

Recent Grants

Articles (16)

RETRACTED: Targeting mechanistic target of rapamycin complex 2 attenuates immunopathology in systemic lupus erythematosus

PI3K-dependant reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.

CPT2-mediated Fatty Acid Oxidation Is Dispensable for Humoral Immunity

PP2A catalytic subunit alpha is critically required for CD8<sup>+</sup> T‐cell homeostasis and antibacterial responses

A Novel Humanized PD-1/PD-L1 Mouse Model Permits Direct Comparison of Antitumor Immunity Generated by Food and Drug Administration–Approved PD-1 and PD-L1 Inhibitors

Immune responses and disease biomarker long-term changes following COVID-19 mRNA vaccination in a cohort of rheumatic disease patients

mTORC2 contributes to systemic autoimmunity

Fatty acid metabolism in adaptive immunity

Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8 + T cells via ME1 up-regulation

A Flare Risk Index Informed by Select Immune Mediators in Systemic Lupus Erythematosus.

Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting Therapy

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Immune checkpoint inhibitor-induced inflammatory arthritis: a novel clinical entity with striking similarities to seronegative rheumatoid arthritis

Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T<sub>reg</sub> Cells.

Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress

Collaborators (2)

Whitney Barham

Ayesha Saleem

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