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Huasong Ai

Associate Professor

Shanghai Jiao Tong University

China

Research Interests

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Professors in Cell Biology

Articles (20)

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2026

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2025

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2025

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2025

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2024

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2024

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2024

Collaborators (1)

Haiteng Deng

Professor/Director

Tsinghua University

CHINA

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Huasong Ai

Research Interests

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Articles (20)

Semisynthesis of Multiphosphorylated and Acetylated Histone Methyltransferase Dot1L Reveals Synergistic Inhibition of Nucleosomal H3K79 Methylation

Steric Gating Contributes to the Preferential Ubiquitin Charging of BIRC6 by UBA6 versus UBA1

Chemical Synthesis of Asymmetric Nucleosomes Reveals Intramolecular Activation of UHRF1 E3 Ligase by H3K9me3

Ferricyanide-mediated direct ligation of peptide hydrazides in neutral water

Chemically Synthesized H3K14Ub Unveils Clr4's IDR‐Mediated Multivalent Nucleosome Recognition in H3K9 Methylation

Development of Substrate-Directed Activity-Based Probes via Disulfide-Trapping for Site-Specific Interrogation of Nucleosomal Deubiquitination

Chemical strategies for trapping fleeting enzymatic complexes in nucleosome ubiquitylation

Structural basis for E4 enzyme Ufd2-catalyzed K48/K29 branched ubiquitin chains

Unique gluing effect of ASXL1 K351 monoubiquitination stimulates the PR-DUB activity

Allosteric activation of RNF20/RNF40–RAD6A-mediated H2BK120 monoubiquitylation by H2BS112 GlcNAcylation

Synthesis of an E2-Ub-nucleosome conjugate to capture the E3 ligase PHF7-catalyzed H3K14 ubiquitination intermediate

Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

Mechanistic Insights into the Stimulation of the Histone H3K9 Methyltransferase Clr4 by Proximal H3K14 Ubiquitination

Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring ubiquitin to form K29/K48-branched polyubiquitination

Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168

The Emerging Role of the Histone H2AK13/15 Ubiquitination: Mechanisms of Writing, Reading, and Erasing in DNA Damage Repair and Disease

Promotion of RNF168‐Mediated Nucleosomal H2A Ubiquitylation by Structurally Defined K63‐Polyubiquitylated Linker Histone H1

Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16

Chemical Synthesis of Human Proteoforms and Application in Biomedicine

Ferricyanide-Promoted Oxidative Activation and Ligation of Protein Thioacids in Neutral Aqueous Media

Collaborators (1)

Haiteng Deng

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