Hyun Lee

Research Associate Professor

University of Chicago

United States

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Hyun Lee is a Research Associate Professor at the University of Illinois at Chicago, USA. His research focuses on therapeutic strategies against viral infections, particularly SARS-CoV-2, as well as innovative approaches for enhancing antibiotic production in microbial systems. He is also engaged in the study of chemotactic migration mechanisms in human cells and the development of small molecule inhibitors. His recent publications reflect a strong emphasis on structure-based analysis and high-throughput screening methodologies.

Articles (18)

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2025

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2023

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2023

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2023

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2023

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2022

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2022

Collaborators (14)

Arnon Lavie

Professor

University of Chicago

UNITED STATES

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Michael Johnson

University of Chicago

UNITED STATES

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Jalees Rehman

UNITED STATES

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Dae Sik Jang

Kyungpook National University

SOUTH KOREA

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Mohammad Shahid Islam

Associate Professor

Delaware State University

UNITED STATES

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Jeremy J. Johnson

UNITED STATES

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José Villegas

Assistant Professor

University of Chicago

UNITED STATES

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JOHN CHRISTMAN

Professor

Ohio State University

UNITED STATES

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gauri shetye

Research Assistant Professor

University of Illinois Chicago (UIC)

UNITED STATES

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Mee-Ngan F. Yap

Associate Professor

Northwestern University Feinberg School of Medicine

UNITED STATES

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Hongmin Li

R. Ken and Donna Coit Endowed Chair Professor

University of Arizona

UNITED STATES

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YOUNG-MEE KIM

Research Assistant Professor

University of Chicago

UNITED STATES

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Steven Goossens

Professor at Ghent University

Ghent University

BELGIUM

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Hak Soo Choi

Associate Professor

Harvard Medical School

UNITED STATES

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Hyun Lee

Research Interests

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Articles (18)

Selective Degradation and Inhibition of SARS-CoV-2 3CLpro by MMP14 Reveals a Novel Strategy for COVID-19 Therapeutics

Enhancing rufomycin production by CRISPR/Cas9-based genome editing and promoter engineering in Streptomyces sp. MJM3502

Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues

Staphylococcal exoribonuclease YhaM destabilizes ribosomes by targeting the mRNA of a hibernation factor

An ISG15-Based High-Throughput Screening Assay for Identification and Characterization of SARS-CoV-2 Inhibitors Targeting Papain-like Protease

Identifying the crucial binding domain of histatin-1 to recombinant TMEM97 in activating chemotactic migration in human corneal epithelial cells

Synergistic Inhibition Guided Fragment-Linking Strategy and Quantitative Structure–Property Relationship Modeling To Design Inhalable Therapeutics for Asthma Targeting CSF1R

Identification of small molecule inhibitors against MMP-14 via High-Throughput screening

α-Mangostin Promotes In Vitro and In Vivo Degradation of Androgen Receptor and AR-V7 Splice Variant in Prostate Cancer Cells

Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD+

CX<sub>3</sub>CR<sub>1</sub>+ Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26.

<i>In vivo</i> stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia.

The Role of Membrane-Type 1 Matrix Metalloproteinase–Substrate Interactions in Pathogenesis

Evaluation of interactions between the hepatitis C virus NS3/4A and sulfonamidobenzamide based molecules using molecular docking, molecular dynamics simulations and binding free energy calculations

Discovery of Nirmatrelvir Resistance Mutations in SARS-CoV-2 3CLpro: A Computational-Experimental Approach

Complement C1q essential for aeroallergen sensitization via CSF1R+ conventional dendritic cells type 2

Anti-Microbial Activity of Aliphatic Alcohols from Chinese Black Cardamom (Amomum tsao-ko) against Mycobacterium tuberculosis H37Rv

Allosteric inhibitors of the main protease of SARS-CoV-2

Collaborators (14)

Arnon Lavie

Michael Johnson

Jalees Rehman

Dae Sik Jang

Mohammad Shahid Islam

Jeremy J. Johnson

José Villegas

JOHN CHRISTMAN

gauri shetye

Mee-Ngan F. Yap

Hongmin Li

YOUNG-MEE KIM

Steven Goossens

Hak Soo Choi

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