Ian Gurrell

Head of DMPK & Translational Medicine

AstraZeneca UK Limited

United Kingdom

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Ian Gurrell is the Head of DMPK & Translational Medicine at AstraZeneca in the United Kingdom. His research focuses on the direct activation of KCC2 to address benzodiazepine refractory status epilepticus, CNS delivery methods for spinal muscular atrophy therapies, and the therapeutic potential of monoclonal antibodies in migraine prevention. Additionally, he investigates pharmacological approaches to enhance tau clearance in tauopathy neurons.

Articles (4)

Year:

2023

Year:

2022

Year:

2020

Year:

2020

Collaborators (3)

Edita Navratilova

Research Assistant Professor

University of Arizona

UNITED STATES

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Sharon Tentarelli

UNITED STATES

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Aidan Evans-Strong

Washington University in St. Louis

UNITED STATES

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Ian Gurrell

Research Interests

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Articles (4)

Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice

Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy.

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine

Collaborators (3)

Edita Navratilova

Sharon Tentarelli

Aidan Evans-Strong

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