Ian MacRae

Professor

Scripps Research

United States

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Ian MacRae is a Professor at Scripps Research in the United States. His research focuses on the molecular mechanisms of RNA silencing, including the roles of Argonautes and PIWI proteins in transposon regulation and microbial defense. Recent publications highlight his work on RNA slicing, microRNA selectivity, and the structural basis for piRNA targeting.

Articles (12)

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2025

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2025

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2024

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2020

Collaborators (3)

Pei-Hsuan Wu

Assistant Professor

University of Geneva

SWITZERLAND

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Gabriel C. Lander

Professor

Scripps Research

UNITED STATES

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Yukihide Tomari

Professor

University of Tokyo

JAPAN

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Ian MacRae

Research Interests

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Articles (12)

A conserved PIWI silencing complex detects piRNA-target engagement

Molecular arms in microbial defense: Argonautes and Cas4 nucleases team up

Assembly of the bacterial ribosome with circularly permuted rRNA

Relaxed targeting rules help PIWI proteins silence transposons

A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength

Structural basis for RNA slicing by a plant Argonaute

GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins

The molecular mechanism of microRNA duplex selectivity of Arabidopsis ARGONAUTE10

A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome

Structural basis for piRNA targeting

miR-122–based therapies select for three distinct resistance mechanisms based on alterations in RNA structure

Robust differential microRNA targeting driven by supplementary interactions in vitro

Collaborators (3)

Pei-Hsuan Wu

Gabriel C. Lander

Yukihide Tomari

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