Ilya Finkelstein

Associate Professor

University of Texas at Austin

United States

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About

Dr. Ilya Finkelstein is an Associate Professor at The University of Texas at Austin, USA. His research primarily focuses on nucleic acid diagnostics, CRISPR technology, and DNA repair mechanisms. Recent articles highlight his contributions to understanding the kinetics of Cas12a, the mechanisms of CRISPR-associated proteins, and the biophysical properties of chromatin condensates.

Articles (18)

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2025

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2021

Collaborators (8)

Valerie De Anda

University of Texas at Austin

UNITED STATES

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University of Texas at Austin

UNITED STATES

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Pedro Leão

Assistant Professor

Radboud University

NETHERLANDS

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Ilya Finkelstein

Research Interests

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Articles (18)

Unleashing high trans-substrate cleavage kinetics of Cas12a for nucleic acid diagnostics

Mechanism of Cas9 inhibition by AcrIIA11

Asgard archaea defense systems and their roles in the origin of eukaryotic immunity

Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Distinct horizontal transfer mechanisms for type I and type V CRISPR-associated transposons

Massively parallel profiling of RNA-targeting CRISPR-Cas13d

CTCF and R-loops are boundaries of cohesin-mediated DNA looping

In diverse conditions, intrinsic chromatin condensates have liquid-like material properties

The MRN complex and topoisomerase IIIa–RMI1/2 synchronize DNA resection motor proteins

High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL

Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends

A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity

Metagenomic discovery of CRISPR-associated transposons

Disintegration promotes protospacer integration by the Cas1-Cas2 complex

CRISPR-Guided Programmable Self-Assembly of Artificial Virus-Like Nucleocapsids

Inhibition of CRISPR-Cas12a DNA targeting by nucleosomes and chromatin

Massively parallel kinetic profiling of natural and engineered CRISPR nucleases

Collaborators (8)

Valerie De Anda

Brett Baker

Makkuni Jayaram

David Taylor

Xiao-chen Bai

William Press

Claus O Wilke

Pedro Leão

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