Irina Kufareva

Associate Adjunct Professor

University of California, San Diego

United States

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About

Irina Kufareva is an Associate Adjunct Professor at the University of California at San Diego. Her research focuses on the mechanisms of chemokine receptor activation and selectivity, with recent articles exploring topics such as the internalization and distribution of CCR5, as well as the structural modeling of chemokine interactions. She has contributed significantly to understanding the intricate relationships between signaling pathways and receptor functionality in immune response mechanisms.

Articles (19)

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2025

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2020

Collaborators (10)

Ariane Jansma

Professor

Point Loma Nazarene University

UNITED STATES

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Martin Gustavsson

Københavns Universitet

DENMARK

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Fiona Murray

University of Aberdeen

UNITED KINGDOM

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Borja Ocón Moreno

Universidad de Granada

SPAIN

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Tracy M. Handel

University of California

UNITED STATES

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Nicola J Smith

Senior Lecturer

UNSW Sydney

AUSTRALIA

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Peter Keov

Monash Institute of Pharmaceutical Sciences

AUSTRALIA

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Juliana M Navia-Pelaez

Assistant Professor

Saint Louis University

UNITED STATES

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Brendan Wilkins

Lecturer, Level B Academic

UNSW Sydney

AUSTRALIA

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oliver hartley

University of Geneva

SWITZERLAND

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Irina Kufareva

Research Interests

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Articles (19)

Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28

Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping

ARRDC3 tyrosine phosphorylation functions as a switch to control c-Src versus WWP2 interactions and distinct scaffolding functions

Traffic control: Mechanisms of ligand-specific internalization and intracellular distribution of CCR5

A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS

Growth factor–dependent phosphorylation of Gαi shapes canonical signaling by G protein–coupled receptors

Global computational analyses of APEX proximity biotinylation data reveal distinct trafficking rules of chemokine receptors CCR2 and CCR5

kboolnet: a toolkit for the verification, validation, and visualization of reaction-contingency (rxncon) models

The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms

Divergent regulation of α-arrestin ARRDC3 function by ubiquitination

Maximizing biological discovery through global computational analyses of unbiased apex biotinylation data on chemokine receptors

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

Orphan receptor GPR37L1 remains unliganded

Retraction Note: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors (Nature Chemical Biology, (2017), 13, 2, (235-242), 10.1038/nchembio.2266)

Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis

Collaborators (10)

Ariane Jansma

Martin Gustavsson

Fiona Murray

Borja Ocón Moreno

Tracy M. Handel

Nicola J Smith

Peter Keov

Juliana M Navia-Pelaez

Brendan Wilkins

oliver hartley

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