Isabella Derler

Has grant

Assistant Professor

Johannes Kepler University Linz

Austria

Research Interests

Explore related searches

Professors in Austria

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

About

Isabella Derler is an Assistant Professor at Johannes Kepler Universität Linz, Austria. Her research focuses on the mechanisms and dynamics of calcium ion channels, with recent publications addressing topics such as STIM proteins, the CRAC channel activation cascade, and the structural dynamics of the Orai complex. Her work contributes significantly to understanding calcium signaling in the context of various diseases, including cancer.

Recent Grants

Grant: Close

Interplay of CRAC and Ca2+ activated K+ ion channels

Open Date: 2020-06-01

Close Date: 2024-05-01

Grant: Close

NOVEL CONTROL OF CALCIUM ENTRY VIA LIGHT-SENSITIVE UNNATURAL AMINO ACIDS

Open Date: 2019-05-01

Close Date: 2021-04-01

Grant: Close

Gating of the Orai channel complex involves outer regions surrounding the pore

Open Date: 2015-01-01

Close Date: 2019-03-01

Grant: Close

Cholesterol regulates Orai currents via an N-terminal cholesterol binding motif

Open Date: 2013-03-01

Close Date: 2017-08-01

Grant: Close

Molecular determinants and stoichiometry of STIM1/Orai activation

Open Date: 2010-03-01

Close Date: 2013-02-01

Articles (14)

Year:

2024

Year:

2024

Year:

2023

Year:

2023

Year:

2021

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Year:

2020

Year:

2020

Year:

2020

Year:

2020

Collaborators (9)

Thomas Renger

Johannes Kepler University Linz

AUSTRIA

View details

Johannes Kepler University Linz

AUSTRIA

View details

Muammer Üçal

AUSTRIA

View details

Heinrich Krobath

AUSTRIA

View details

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts before you send them.

Isabella Derler

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (14)

Genetic code expansion, an emerging tool in the Ca2+ ion channel field

Insights into the dynamics of the Ca2+ release-activated Ca2+ channel pore-forming complex Orai1

Swing‐out opening of stromal interaction molecule 1

Activation mechanisms and structural dynamics of STIM proteins

Orai1 Boosts SK3 Channel Activation

Transmembrane Domain 3 (TM3) Governs Orai1 and Orai3 Pore Opening in an Isoform-Specific Manner.

The Orai Pore Opening Mechanism.

Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade

Blockage of Store-Operated Ca<sup>2+</sup> Influx by Synta66 is Mediated by Direct Inhibition of the Ca<sup>2+</sup> Selective Orai1 Pore

Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.

Molecular Choreography and Structure of Ca<sup>2+</sup> Release-Activated Ca<sup>2+</sup> (CRAC) and K<sub>Ca2+</sub> Channels and Their Relevance in Disease with Special Focus on Cancer.

Inactivation-mimicking block of the epithelial calcium channel TRPV6

Natural photoswitches expose STIM1 activation steps.

Collaborators (9)

Thomas Renger

Tony Christian Schmidt

Linda Waldherr

Rainer Schindl

Adela Tiffner

Matthias Hediger

Herwig Grabmayr

Muammer Üçal

Heinrich Krobath

Make your next move.