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Ivan Vokřál

Assistant Professor

Charles University, Faculty of Pharmacy in Hradec Kralove

Czech Republic

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Research Interests

Pharmacology

50%

Pharmacotherapy

30%

Ecotoxicology

30%

Drug Metabolism

30%

Pharmacokinetic

30%

Toxicology

20%

Drug Transport

20%

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Recent Grants

Grant: Close

In vitro and ex vivo models to study drug-drug interactions of antiviral drugs on intestinal transporters

Open Date: 2018-01-01

Close Date: 2020-12-31

Articles13

Biotransformation of anthelmintics in nematodes in relation to drug resistance

Article Link

Year:

2025

Anthelmintics in the environment: Their occurrence, fate, and toxicity to non-target organisms

Article Link

Year:

2023

Albendazole from ovine excrements in soil and plants under real agricultural conditions: Distribution, persistence, and effects

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Year:

2023

Effect of P-glycoprotein and Cotreatment with Sofosbuvir on the Intestinal Permeation of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Fumarate

Article Link

Year:

2023

Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation

Article Link

Year:

2022

Evaluation of the Potency of Anti-HIV and Anti-HCV Drugs to Inhibit P-Glycoprotein Mediated Efflux of Digoxin in Caco-2 Cell Line and Human Precision-Cut Intestinal Slices

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Year:

2022

Precision-cut rat placental slices as a model to study sex-dependent inflammatory response to LPS and Poly I:C

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Year:

2022

Environmental circulation of the anthelmintic drug albendazole affects expression and activity of resistance-related genes in the parasitic nematode Haemonchus contortus

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Year:

2022

Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes

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Year:

2021

Proof of the environmental circulation of veterinary drug albendazole in real farm conditions

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Year:

2021

Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

Article Link

Year:

2021

Use of Precision-Cut Tissue Slices as a Translational Model to Study Host-Pathogen Interaction

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Year:

2021

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

Article Link

Year:

2020

Collaborators6

Thomas Kurz

Heinrich Heine University Düsseldorf

GERMANY

Lukáš Červený

Associate Professor

Univerzita Karlova Farmaceutická Fakulta v Hradci Králové

CZECH REPUBLIC

Hana Vlčková

lecturer and research analytical chemist

Charles University, Faculty of Pharmacy in Hradec Kralove

CZECH REPUBLIC

Rona Karahoda

Assistant Professor

Charles University

CZECH REPUBLIC

Ondřej Holas

Charles University

CZECH REPUBLIC

Ondrej Martinec

Assistant Professor

Charles University, Faculty of Medicine in Pilsen

CZECH REPUBLIC

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