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Izumi Horikawa

National Institutes of Health

United States

Research Interests

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Professors in United States Professors in Cell Biology Cell Biology professors in United States

Articles (10)

Year:

2026

Year:

2026

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Year:

2024

Year:

2021

Year:

2020

Collaborators (4)

James Inglese

Principal Investigator

National Institutes of Health

UNITED STATES

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Jilian Melamed

Research Assistant Professor

University of Pennsylvania

UNITED STATES

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drew weissman

Professor

University of Pennsylvania

UNITED STATES

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Shinji Nakamichi

Assistant Professor

Nippon Medical School

JAPAN

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Izumi Horikawa

Research Interests

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Articles (10)

Δ133p53α, a senescence-inhibitory p53 isoform, attenuates accelerated aging in progeria mice

The senescence-inhibitory p53 isoform Δ133p53α represses the proinflammatory chemokine CXCL10 in progeria model mice and naturally aged mice.

The senescence-inhibitory p53 isoform Δ133p53α: enhancing cancer immunotherapy and exploring novel therapeutic approaches for senescence-associated diseases

Δ133p53α-mediated inhibition of astrocyte senescence and neurotoxicity as a possible therapeutic approach for neurodegenerative diseases

A Quantitative High-Throughput Screen Identifies Compounds that Upregulate the p53 Isoform Δ133p53α and Inhibit Cellular Senescence

SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells.

Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence

Astrocyte senescence and SASP in neurodegeneration: tau joins the loop

Balancing and Differentiating p53 Activities toward Longevity and No Cancer?

Collaborators (4)

James Inglese

Jilian Melamed

drew weissman

Shinji Nakamichi

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