J. Robert Lane

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Associate Professor in Molecular Pharmacology

University of Nottingham

United Kingdom

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J. Robert Lane is an Associate Professor in Molecular Pharmacology at the University of Nottingham, UK. His research interests include the discovery and optimization of positive allosteric modulators, particularly focusing on the D3 dopamine receptor and M1 receptor. Recent publications highlight his work on the pharmacological properties of opioids and their effects on respiratory depression, contributing significantly to the understanding of safer analgesics.

Recent Grants

Grant: Close

New tools for acute spatiotemporal control of GPCR signalling in vivo

Open Date: 2020-11-01

Close Date: 2023-10-31

Grant: Close

New tools for acute spatiotemporal control of GPCR signalling in vivo

Open Date: 2020-11-01

Close Date: 2023-10-31

Grant: Close

Schaefer Research Scholarship

Open Date: 2017-01-01

Close Date:

Grant: Close

Allosteric Targeting of the Dopamine D2 Receptor: A novel Approach for the Treatment of Parkinson's Disease

Open Date: 2016-01-01

Close Date: 2019-01-01

Grant: Close

Adrenergic regulation of tumor inflammation and metastatic dissemination

Open Date: 2014-01-01

Close Date: 2016-01-01

Articles (16)

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2025

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2021

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2021

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2021

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2021

Collaborators (8)

Rosalba Sortino

Institute for bioengineering of Catalonia, IBEC

SPAIN

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Meritxell Canals

Professor at School of Life Sciences

University of Nottingham

UNITED KINGDOM

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Stéphane A. Laporte

McGill University

CANADA

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Maria Hauge Pedersen

Københavns Universitet

DENMARK

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Alessandro Bonifazi

Associate Professor

University of Texas Medical Branch at Galveston

UNITED STATES

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Daniel Scott

Laboratory Head

Florey Institute of Neuroscience and Mental Health

AUSTRALIA

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Martin Stone

MONASH UNIVERSITY

AUSTRALIA

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Vsevolod Katritch

University of Southern California

UNITED STATES

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J. Robert Lane

Research Interests

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About

Recent Grants

Articles (16)

Discovery, Characterization, and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D3 Dopamine Receptor

In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling

Innenrücktitelbild: Photo‐BQCA: Postiv allostere Modulatoren ermöglichen die optische Kontrolle des M1‐Rezeptors (Angew. Chem. 47/2024)

Inside Back Cover: Photo‐BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor (Angew. Chem. Int. Ed. 47/2024)

Photo‐BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor

Photo‐BQCA: Postiv allostere Modulatoren ermöglichen die optische Kontrolle des M1‐Rezeptors

Assessment of the potential of novel and classical opioids to induce respiratory depression in mice

Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D3 (D3R) and μ-Opioid (MOR) Receptor Ligands as Potentially Safer Analgesics

The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα<sub>z</sub>

Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10

Enantioenriched positive allosteric modulators display distinct pharmacology at the dopamine d<sub>1</sub> receptor

Erratum: Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists (Science Signaling (2021) DOI: 10.1126/scisignal.aaz3140)

New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D<sub>2</sub> receptor regulation and signaling

Novel Dual-Target μ-Opioid Receptor and Dopamine D<sub>3</sub>Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management

Pharmacological characterization of the imipridone anticancer drug onc201 reveals a negative allosteric mechanism of action at the d2 dopamine receptors

Collaborators (8)

Rosalba Sortino

Meritxell Canals

Stéphane A. Laporte

Maria Hauge Pedersen

Alessandro Bonifazi

Daniel Scott

Martin Stone

Vsevolod Katritch

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