J. Scott Lee

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Assistant Professor

University of Colorado Anschutz Medical Campus

United States

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Dr. J. Scott Lee is an Assistant Professor at the University of Colorado Anschutz Medical Campus, USA. His research focuses on the interplay between gut microbiota and host responses in the context of inflammatory bowel disease, with recent contributions examining purine metabolism, epithelial barrier function, and microbial metabolites. He has published extensively on topics such as colonic wound healing and the role of microbiota-derived substances in intestinal health.

Recent Grants

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Microbial-derived purines in intestinal homeostasis

Open Date: 2019-06-01

Close Date: 2021-05-31

Articles (10)

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2025

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2020

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2020

Collaborators (1)

Matthew Skelton

Assistant Professor

Cincinnati Children's Hospital Medical Center

UNITED STATES

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J. Scott Lee

Research Interests

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About

Recent Grants

Articles (10)

E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult

Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis.

Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice.

Revisiting the "starved gut" hypothesis in inflammatory bowel disease.

IL-38 Gene Deletion Worsens Murine Colitis.

Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics.

Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function.

Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor.

Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function

Microbiota-Sourced Purines Support Wound Healing and Mucous Barrier Function

Collaborators (1)

Matthew Skelton

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