JACEK SAPA

professor

Uniwersytet Jagiellonski Collegium Medicum

Poland

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Research Interests

Pharmaceutical Chemistry

70%

Pharmacology

100%

Neuropharmacology

100%

Endocannabinoid

80%

Drug Formulation

70%

Ligand Chemistry

40%

Supramolecular Chemistry

40%

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Recent Grants

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.”Częściowi agoniści receptorów -2-adrenergicznych jako nowa perspektywa skutecznego i bezpiecznego zmniejszania masy ciała i otyłości”

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.„Częściowi agoniści receptorów -1A/D-adrenergicznych jako potencjalne związki poprawiające parametry urodynamiczne w łagodnym przeroście gruczołu krokowego

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Articles20

Potential Anti-Amnesic Activity of a Novel Multimodal Derivative of Salicylamide, JJGW08, in Mice

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2023

Novel Multimodal Salicylamide Derivative with Antidepressant-like, Anxiolytic-like, Antipsychotic-like, and Anti-Amnesic Activity in Mice

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2023

The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α1-Adrenoceptors Antagonists

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2023

Manifestations of Liver Impairment and the Effects of MH-76, a Non-Quinazoline α1-Adrenoceptor Antagonist, and Prazosin on Liver Tissue in Fructose-Induced Metabolic Syndrome

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2023

Efficacy of the Multi-Target Compound E153 in Relieving Pain and Pruritus of Different Origins

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2023

Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity.

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2022

Synthesis and antinociceptive activity of four 1H‐isoindolo‐1,3(2H)‐diones

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2022

Novel Arylpiperazine Derivatives of Salicylamide with α1-Adrenolytic Properties Showed Antiarrhythmic and Hypotensive Properties in Rats

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2022

Antipsychotic- and Anxiolytic-like Properties of a Multimodal Compound JJGW08 in Rodents

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Year:

2022

HBK-10, A Compound with α1-Adrenolytic Properties, Showed Antiarrhythmic and Hypotensive Effects in Rats

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2022

Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors

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2021

The Antiarrhythmic Activity of Novel Pyrrolidin-2-one Derivative S-75 in Adrenaline-Induced Arrhythmia

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2021

Ligand role on insulin-mimetic properties of vanadium complexes. Structural and biological studies

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2021

PSB 603 – a known selective adenosine A2B receptor antagonist – has anti-inflammatory activity in mice

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2021

Tridentate ONO ligands in vanadium(III-V) complexes - synthesis, characterization and biological activity

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Year:

2021

Bioresearch of New 1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones

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2020

Characterization and antidiabetic activity of salicylhydrazone Schiff base vanadium(IV) and (V) complexes

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2020

KD-64—A new selective A<inf>2A</inf> adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist—Caffeine does not reduce diet-induced obesity in mice

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2020

Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model

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2020

Synthesis, coordination properties and biological activity of vanadium complexes with hydrazone Schiff base ligands

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Year:

2020

Collaborators9

Magdalena Kotańska

POLAND

DOMINIKA SZKATUŁA

Medical University of Silesia

POLAND

Elżbieta Wyska

Jagiellonian University Medical College

POLAND

Jadwiga Handzlik

POLAND

Henryk Marona

Professor

Jagiellonian University Medical College

POLAND

Klaudia Lustyk

Assistant Professor

Uniwersytet Jagiellonski Collegium Medicum

POLAND

Karolina Pytka

Associate Professor

Uniwersytet Jagiellonski Collegium Medicum

POLAND

Grażyna Chłoń-Rzepa

Assistant Professor with Habilitation

Jagiellonian University Medical College

POLAND

Dorota Łażewska

Jagiellonian University Medical College

POLAND

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