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Jacob Scott

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Professor

University of Rochester

United States

Research Interests

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Recent Grants

Grant: Open

Extending experimental evolutionary game theory in cancer in vivo to enable clinical translation: integrating spatio-temporal dynamics using mathematical modeling

Open Date: 2023-08-01

Close Date: 2028-07-31

Grant: Open

Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies

Open Date: 2022-09-14

Close Date: 2027-07-31

Grant: Close

Evolutionary experimentation and radio-genomics in endometrial cancer.

Open Date: 2022-07-01

Close Date: 2025-06-30

Grant: Close

Perturbing the evolutionary drivers of targeted therapy resistance in NSCLC

Open Date: 2020-07-01

Close Date: 2024-06-30

Grant: Open

Exploiting Ecology and Evolution to Prevent Therapy Resistance in EGFR-Driven Lung Cancer

Open Date: 2019-12-01

Close Date: 2026-11-30

Articles (16)

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2023

Collaborators (8)

J Arvid Ågren

Assistant Professor

Case Western Reserve University

UNITED STATES

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Dmitri Finkelshtein

Associate Professor

Swansea University

UNITED KINGDOM

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Andriy Marusyk

Associate member

H Lee Moffitt Cancer Center and Research Institute

UNITED STATES

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Andrew Dhawan

Neuro-Oncologist

Cleveland Clinic

UNITED STATES

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Matti Nykter

Professor

University of Tampere

FINLAND

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Otso Ovaskainen

University of Jyväskylä

FINLAND

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Sara Hamis

Assistant Professor

Uppsala University

SWEDEN

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Christopher McFarland

Assistant Professor

Case Western Reserve University School of Medicine

UNITED STATES

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Jacob Scott

Research Interests

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Recent Grants

Articles (16)

The Evolution of Fitness Landscapes: From Visualizing Evolution to Controlling It

Age identifies cancer drivers hidden within the genome

Adaptive therapy and its challenges

Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus

Personalizing chemotherapy drug selection using a novel transcriptomic chemogram

Wound complications and local recurrence do not differ when using interstitial brachytherapy versus external beam radiation therapy for soft tissue sarcoma

Fitness seascapes are necessary for realistic modeling of the evolutionary response to drug therapy

Frequency-Dependent Ecological Interactions Increase the Prevalence, and Shape the Distribution, of Preexisting Drug Resistance

Quantitative evaluation of DNA damage repair dynamics to elucidate predictors of autism vs. cancer in individuals with germline PTEN variants

Reinforcement learning informs optimal treatment strategies to limit antibiotic resistance

Diverse mutant selection windows shape spatial heterogeneity in evolving populations

Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems

Viruses, cancers, and evolutionary biology in the clinic: a commentary on Leeks et al. 2023

Graph ‘texture’ features as novel metrics that can summarize complex biological graphs

Radio-immune response modelling for spatially fractionated radiotherapy

Exploiting convergent phenotypes to derive a pan-cancer cisplatin response gene expression signature

Collaborators (8)

J Arvid Ågren

Dmitri Finkelshtein

Andriy Marusyk

Andrew Dhawan

Matti Nykter

Otso Ovaskainen

Sara Hamis

Christopher McFarland

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