Jae-Hyuck Shim

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Associate professor

University of Massachusetts Chan Medical School

United States

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About

Jae-Hyuck Shim is an Associate Professor at the University of Massachusetts Medical School, located in the United States. His research primarily focuses on skeletal health, exploring themes such as osteoporosis, osteogenesis imperfecta, and the role of various proteins in bone formation and degradation. Recent publications highlight advancements in gene therapy strategies and innovative technologies aimed at bone-targeting drug delivery.

Recent Grants

Grant: Close

Identification of novel regulators governing osteoclast-osteoblast coupling

Open Date: 2016-03-01

Close Date: 2021-02-01

Grant: Close

Promoting skeletal healing through the Schnurri-3 pathway

Open Date: 2016-02-01

Close Date: 2017-01-01

Grant: Close

Identification and Characterization of Bone-related Genetic Variants in Families

Open Date: 2014-07-01

Close Date: 2017-07-01

Grant: Close

MEKK2 is a novel crosstalk modulator regulating the β-catenin pathway and growth factor pathway in osteoblasts.

Open Date: 2014-01-01

Close Date:

Grant: Close

Increasing Bone Formation via the Shn3 Pathway: A New Paradigm for Drug Development

Open Date: 2014-01-01

Close Date: 2017-02-01

Articles (17)

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2025

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2022

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2022

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2022

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2022

Collaborators (7)

Edward Hsiao

University of California, San Francisco

UNITED STATES

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Won-Taek Oh

Assistant Professor

Yonsei University College of Medicine

SOUTH KOREA

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Marjolein C.H. van der Meulen

Cornell University

UNITED STATES

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Elisabeth Eekhoff

Prof, MD, PhD, staff member (and research)

Amsterdam UMC Locatie VUmc

NETHERLANDS

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Odile Filhol

INSERM U1148

FRANCE

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Ton Schoenmaker

University of Amsterdam

NETHERLANDS

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Aijaz Ahmad John

University of Massachusetts Chan Medical School

UNITED STATES

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Jae-Hyuck Shim

Research Interests

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About

Recent Grants

Articles (17)

The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

Comprehensive Review of Osteogenesis Imperfecta: Current Treatments and Future Innovations

Engineering a targeted and safe bone anabolic gene therapy to treat osteoporosis in alveolar bone loss

Advances in Bone-Targeting Drug Delivery: Emerging Strategies Using Adeno-Associated Virus

Development of AAV-Mediated Gene Therapy Approaches to Treat Skeletal Diseases

Sensors in Bone: Technologies, Applications, and Future Directions

AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in Fibrodysplasia Ossificans Progressiva

Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis

Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration

Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.

WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects.

AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles.

The Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Pathway in Osteoblasts

Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes.

Collaborators (7)

Edward Hsiao

Won-Taek Oh

Marjolein C.H. van der Meulen

Elisabeth Eekhoff

Odile Filhol

Ton Schoenmaker

Aijaz Ahmad John

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