James A. Nieman

University of Alberta

Canada

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Articles (7)

Year:

2023

Year:

2023

Year:

2021

Year:

2021

Year:

2021

Year:

2020

Year:

2020

Collaborators (5)

Tess Lamer

University of Alberta

CANADA

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Mostofa Hena

University of Alberta

CANADA

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Joanne Lemieux

Professor

University of Alberta

CANADA

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Michael Houghton

Director, Li Ka Shing Applied Virology Institut/ Professor

University of Alberta

CANADA

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Conrad Fischer

Assistant Professor

Barry University

UNITED STATES

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James A. Nieman

Research Interests

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Articles (7)

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism

Deuteration for Metabolic Stabilization of SARS-CoV-2 Inhibitors GC373 and Nirmatrelvir

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and <i>in Vitro</i> Biological Stability.

Improved SARS-CoV-2 M<sup>pro</sup> inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors

Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.

Collaborators (5)

Tess Lamer

Mostofa Hena

Joanne Lemieux

Michael Houghton

Conrad Fischer

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