James Brien

Assistant Professor

University of Kentucky

United States

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James Brien is an Assistant Professor at the University of Kentucky, USA. His research focuses on immunological responses to various viral pathogens, including SARS-CoV-2, MERS-CoV, and flaviviruses, with a particular interest in antiviral sensing and type I interferon signaling. He has published recent articles examining the immune system's response to viral infections and the development of effective vaccination strategies.

Articles (10)

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2024

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2022

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2022

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2021

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2021

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2020

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2020

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2020

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2020

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2020

Collaborators (9)

AMRENDRA KUMAR

Research Assistant Professor

Vanderbilt University Medical Center

UNITED STATES

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Todd Green

University of Alabama, Tuscaloosa

UNITED STATES

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Amelia Pinto

Assistant Professor

University of Kentucky

UNITED STATES

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Tae-Hyuk Ahn

Saint Louis University

UNITED STATES

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Enbal Shacham

Saint Louis University

UNITED STATES

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Ana M Espino

University of Puerto Rico, Medical Sciences Campus

UNITED STATES

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John T. Wilson

Vanderbilt University

UNITED STATES

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R. Glenn King

The University of Alabama

UNITED STATES

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Kevin Harrod

Endowed Chair and Professor

The University of Alabama

UNITED STATES

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James Brien

Research Interests

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Articles (10)

Spatial examination of social and environmental drivers of Middle East respiratory syndrome coronavirus (MERS-CoV) across Kenya

Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination

Roles of antiviral sensing and type I interferon signaling in the restriction of SARS-CoV-2 replication

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge

Function Is More Reliable than Quantity to Follow Up the Humoral Response to the Receptor-Binding Domain of SARS-CoV-2-Spike Protein after Natural Infection or COVID-19 Vaccination

Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

Heterotypic immunity against vaccinia virus in an HLA-B*07:02 transgenic mousepox infection model

Current Flavivirus Research Important for Vaccine Development

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2

Collaborators (9)

AMRENDRA KUMAR

Todd Green

Amelia Pinto

Tae-Hyuk Ahn

Enbal Shacham

Ana M Espino

John T. Wilson

R. Glenn King

Kevin Harrod

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