James Crowe

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Professor and Ann Scott Carell Chair

Vanderbilt University School of Medicine

United States

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James Crowe is a Professor and the Ann Scott Carell Chair at Vanderbilt University School of Medicine in the United States. His research focuses on the development of mRNA vaccines and the mechanisms of antibody neutralization against various viruses, including Marburg, Rift Valley fever, and chikungunya. Recent publications highlight his work on human monoclonal antibodies and their potential in protective therapies.

Recent Grants

Grant: Close

Human neutralizing monoclonal antibodies for Rift Valley fever virus

Open Date: 2013-06-01

Close Date: 2015-05-31

Grant: Close

Molecular Determinants of Cross-Reactive Antibody Response to Influenza in Humans

Open Date: 2012-08-15

Close Date: 2016-07-31

Grant: Close

Virology Training Program

Open Date: 2010-05-01

Close Date: 2015-04-30

Grant: Close

Multi-Laser Flow Cytometer for Polychromatic Analysis

Open Date: 2010-03-04

Close Date: 2011-03-03

Grant: Close

Genetic &structural basis for viral neutralization:Vaccinia and Influenza virus

Open Date: 2009-09-30

Close Date: 2014-09-29

Articles (15)

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2022

Collaborators (12)

Daved Fremont

Washington University School of Medicine

UNITED STATES

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Thomas A. Bowden

University of Oxford

UNITED KINGDOM

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Andrew Flyak

Assistant Professor

Cornell University

UNITED STATES

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Amy Hartman

University of Pittsburgh

UNITED STATES

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Alexis Janke

Vanderbilt University Medical Center

UNITED STATES

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Jens Meiler

Vanderbilt University

UNITED STATES

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B.V.Venkataram Prasad

Professor

Baylor College of Medicine

UNITED STATES

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Eric P. Skaar

Vanderbilt University Medical Center

UNITED STATES

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Jinhui Dong

Vanderbilt University

UNITED STATES

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Justin Julander

Research Professor

Utah State University

UNITED STATES

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Cynthia McMillen

University of Pittsburgh

UNITED STATES

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Jarrod Mousa

Assistant Professor

University of Georgia

UNITED STATES

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James Crowe

Research Interests

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About

Recent Grants

Articles (15)

Marburg virus glycoprotein mRNA vaccine is more protective than a virus-like particle-forming mRNA vaccine

Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance

Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses

Potent HPIV3-neutralizing IGHV5-51 Antibodies Identified from Multiple Individuals Show L Chain and CDRH3 Promiscuity.

Potent neutralizing human monoclonal antibodies protect from inhalational Rift Valley fever virus

A highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model

Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody

A chikungunya virus–like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans

Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies

Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity

The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta

Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods

Repeated exposure to heterologous hepatitis C viruses associates with enhanced neutralizing antibody breadth and potency

Human Monoclonal Antibodies to Escherichia coli Outer Membrane Protein A Porin Domain Cause Aggregation but Do Not Alter In Vivo Bacterial Burdens in a Murine Sepsis Model

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

Collaborators (12)

Daved Fremont

Thomas A. Bowden

Andrew Flyak

Amy Hartman

Alexis Janke

Jens Meiler

B.V.Venkataram Prasad

Eric P. Skaar

Jinhui Dong

Justin Julander

Cynthia McMillen

Jarrod Mousa

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