James Davie

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Full Professor

University of Manitoba

Canada

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About

James Davie is a Full Professor at the University of Manitoba, Canada. His research areas include epigenetics, cancer treatment, and gene regulation, as evidenced by his recent publications on topics such as DNA intercalating drugs, differential histone modifications in colorectal cancer, and the role of lysine acetyltransferases in neurodevelopment. He is actively involved in advancing the understanding of protein arginine methyltransferase 1 and its implications in biological processes.

Recent Grants

Grant: Close

Investigating the molecular and cellular abnormalities of the brain in Rett Syndrome

Open Date: 2022-07-01

Close Date: 2023-06-01

Grant: Close

Targeted inhibition of DNA methyltransferase

Open Date: 2022-04-01

Close Date: 2024-03-01

Grant: Close

Protein arginine methyltransferase directed epigenetic networks

Open Date: 2021-07-01

Close Date: 2023-06-01

Grant: Close

Determine how the interaction between SARS-CoV-2 spike protein and angiotensinconverting enzyme 2 (ACE2) affect viral spread and the severity of COVID-19 outcomes

Open Date: 2021-07-01

Close Date: 2022-06-01

Grant: Close

Oligonucleotide targeted repression of the expression of HOXA9 for the treatment of ML Lrearranged leukemia

Open Date: 2021-04-01

Close Date: 2026-03-01

Articles (19)

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2021

Collaborators (3)

Ahmed Ashraf

University of Manitoba

CANADA

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Mojgan Rastegar

Full Professor

University of Manitoba

CANADA

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Meaghan Jones

Assistant Professor

University of Manitoba

CANADA

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James Davie

Research Interests

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About

Recent Grants

Articles (19)

DNA intercalating drugs: Mechanisms of action in cancer treatment

Differential H3K4me3 Domains in Normal and Colorectal Cancer Cells Reveal Novel Epigenetic Targets

Proceedings of the Canadian Society for Molecular Biosciences (CSMB) 2024 Conference — Gene Regulation: From Cells to Systems

Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1

Histone H4 asymmetrically dimethylated at arginine 3 (H4R3me2a), a mark of super-enhancers

Protein arginine methyltransferase 1, a major regulator of biological processes

Artificial intelligence and deep learning algorithms for epigenetic sequence analysis: A review for epigeneticists and AI experts

Neurodevelopmental functions and activities of the KAT3 class of lysine acetyltransferases

Broad histone H4 monomethylation marks expressed genes involved in translation

Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states

MeCP2 is the Protector of Epigenome Integrity, Membrane-Less Nuclear Architecture, and Stability of Chromatin Assembly

Integrative analysis reveals novel associations between DNA methylation and the serum metabolome of adolescents with type 2 diabetes: A cross-sectional study.

Bioinformatic Analyses of Broad H3K79me2 Domains in Different Leukemia Cell Line Data Sets.

Differential expression of HNF1A and HNF1A‐AS1 in colon cancer cells

The key role of differential broad H3K4me3 and H3K4ac domains in breast cancer

The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes

Mitogen-induced transcriptional programming in human fibroblasts.

Transcriptionally Active Chromatin-Lessons Learned from the Chicken Erythrocyte Chromatin Fractionation.

Introduction: Genome Biology.

Collaborators (3)

Ahmed Ashraf

Mojgan Rastegar

Meaghan Jones

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