James McLachlan

Associate Professor

Tulane University School of Medicine

United States

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James McLachlan is an Associate Professor at Tulane University School of Medicine in the United States. His research focuses on immunology, specifically in the development of vaccines and adjuvants, as well as the immune responses to various pathogens. Recent publications include studies on the adjuvant properties of bacterial outer membrane vesicles and their effects on T cell responses, as well as investigating the relationship between age, BMI, and antibody responses to SARS-CoV-2.

Articles (11)

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2024

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2023

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2023

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2022

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2021

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (2)

Richard Zimmerman

Professor with tenure

University of Pittsburgh

UNITED STATES

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Anita McElroy

University of Pittsburgh

UNITED STATES

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James McLachlan

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Articles (11)

A novel outer membrane vesicle adjuvant improves vaccine protection against Bordetella pertussis

The Adjuvant Combination of dmLT and Monophosphoryl Lipid A Activates the Canonical, Nonpyroptotic NLRP3 Inflammasome in Dendritic Cells and Significantly Interacts to Expand Antigen-Specific CD4 T Cells

Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization

SARS-CoV-2 Antibody Response Is Associated with Age and Body Mass Index in Convalescent Outpatients

An outer membrane vesicle-adjuvanted oral vaccine protects against lethal, oral salmonella infection

Bacterial-derived outer membrane vesicles are potent adjuvants that drive humoral and cellular immune responses

Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine

IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4<sup>+</sup> T cell responses

Salmonella Biofilm Formation, Chronic Infection, and Immunity Within the Intestine and Hepatobiliary Tract

Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations

Control of persistent salmonella infection relies on constant thymic output despite increased peripheral antigen-specific T cell immunity

Collaborators (2)

Richard Zimmerman

Anita McElroy

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