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James P. O'Gara

Professor

National University of Ireland Galway

Ireland

Has grant

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Research Interests

Microbiology

80%

Biochemistry

30%

Antibiotic Resistance

50%

Antimicrobial Research

50%

Transporter Biology

40%

Metabolic Biology

30%

Bacterial Physiology

30%

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Recent Grants

Grant: Close

Targeting membrane transporters to increase antibiotic susceptibility in bacterial pathogens

Open Date: 2020-12-01

Close Date: 2024-12-01

Grant: Close

Diabetic Foot Disease: from PRevention to treatment to IMproved patient Outcomes (DFD PRIMO)

Open Date: 2020-04-01

Close Date: 2025-03-01

Grant: Close

Using guanine to re-sensitise MRSA to methicillin: Is purine nucleotide homeostasis the Achilles' heel of MRSA antibiotic resistance?

Open Date: 2019-12-01

Close Date: 2023-12-01

Grant: Close

IRC Postgraduate Scholarship

Open Date: 2019-10-01

Close Date: 2023-09-01

Grant: Close

Repurposing D-cycloserine and related drugs to overcome resistance resistance to beta-lactam antibiotics in bacterial pathogens

Open Date: 2017-04-01

Close Date: 2018-03-01

Articles19

A Scoping Review to Identify Clinical Signs, Symptoms and Biomarkers Reported in the Literature to Be Indicative of Biofilm in Chronic Wounds

Article Link

Year:

2025

Use of the bacteriophage-derived endolysin CHAPK-SH3blys as a potent novel treatment for biofilm-associated Staphylococcus aureus wound infections

Article Link

Year:

2025

A D-alanine aminotransferase S 180 F substitution confers resistance to β-chloro-D-alanine in Staphylococcus aureus via antibiotic inactivation

Article Link

Year:

2025

A low acriflavine dose strongly potentiates the antimicrobial effect of blue light on Staphylococcus aureus

Article Link

Year:

2025

Potent antimicrobial activity of hydrogel loaded with the antimicrobial peptide, D-Bac8c2,5 Leu, against monospecies and polymicrobial biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

Article Link

Year:

2025

The pathogenicity and virulence of the opportunistic pathogen Staphylococcus epidermidis

Article Link

Year:

2024

Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics.

Article Link

Year:

2023

Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics

Article Link

Year:

2023

Sponge-derived fatty acids inhibit biofilm formation of MRSA and MSSA by down-regulating biofilm-related genes specific to each pathogen

Article Link

Year:

2023

Staphylococcus Great Britain and Ireland 2023 (StaphGBI 2023) Conference Report

Article Link

Year:

2023

Signs, symptoms and or biomarkers reported to indicate biofilm in chronic wounds: an edelphi consensus protocol.

Article Link

Year:

2023

Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics

Article Link

Year:

2021

Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics

Article Link

Year:

2021

Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process

Article Link

Year:

2021

Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process

Article Link

Year:

2021

Enzyme-Functionalized Mesoporous Silica Nanoparticles to Target Staphylococcus aureus and Disperse Biofilms

Article Link

Year:

2021

The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate β-lactam Resistance in MRSA by stabilizing Lipoteichoic Acids

Article Link

Year:

2021

The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate beta-lactam Resistance in MRSA by stabilizing Lipoteichoic Acids

Article Link

Year:

2021

Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus

Article Link

Year:

2021

Collaborators11

eoin casey

Professor

Dublin City University

IRELAND

Aoife Boyd

University of Galway

IRELAND

Dhananjay Shinde

Assistant Professor

University of Nebraska Medical Center

UNITED STATES

Merve S. Zeden

IRELAND

Akke Vellinga

Professor Epidemiology

Dublin City University

IRELAND

Angelika Gründling

Professor of Molecular Microbiology

Imperial College London

UNITED KINGDOM

Eoghan O'Neill

Associate Professor and Consultant Microbiologist

Royal College of Surgeons in Ireland

IRELAND

Rebecca M. Corrigan

University of Sheffield

UNITED KINGDOM

Abina Crean

Professor of Pharmaceutics

University College Cork

IRELAND

Aidan Coffey

Professor

Munster Technological University

IRELAND

Guoqing Xia

Senior Lecturer

The University of Manchester

UNITED KINGDOM

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