James Wheless

Professor & Chief of Pediatric Neurology

United States

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James Wheless is a Professor and Chief of Pediatric Neurology at UTHSC. His research focuses on pediatric epilepsy, with recent articles examining topics such as genetic variants associated with developmental epileptic encephalopathy, pharmacokinetics of diazepam nasal spray, and the safety and efficacy of vagus nerve stimulation therapies. His work emphasizes the interplay between pharmacological treatments and their impact on pediatric patients, particularly concerning conditions such as Dravet Syndrome and Lennox–Gastaut syndrome.

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2025

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2022

Collaborators (8)

Wendyl D'Souza

Associate Professor of Neuroepidemiology & Health Services Research

University of Melbourne

AUSTRALIA

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Anita N. Datta

CANADA

ITALY

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James Wheless

Research Interests

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Articles (20)

Biallelic ACSF3 variants with combined malonic and methylmalonic acidemia and associated developmental epileptic encephalopathy phenotype: A novel genotype-phenotype correlation

Pharmacokinetics and 180‐day safety of diazepam nasal spray in pediatric patients with epilepsy aged 2–5 years

Vagus nerve stimulation in Lennox–Gastaut syndrome: Twenty‐four‐month data and experience from the CORE‐VNS study

Dysphagia in Epilepsy Patients

Role of cholesterol in modulating brain hyperexcitability

Use of Stiripentol in Dravet Syndrome: A Guide for Clinicians

A retrospective review of reclassification of Variants of Uncertain Significance in a pediatric epilepsy cohort undergoing genetic panel testing.

Expert opinion on use of vagus nerve stimulation therapy in the management of pediatric epilepsy: A Delphi consensus study

Safety profile of abdominal magnetic resonance imaging (MRI) performed for renal disease surveillance in tuberous sclerosis complex patients with vagus nerve stimulation

Impact of Age and Concurrent Antiseizure Medication Use on Lacosamide Dose to Concentration Ratio and Dosing in Pediatric Patients

Effectiveness, safety and tolerability of perampanel by age group when used to treat people with focal and generalized epilepsy in clinical practice: The PERMIT Extension study

Treatment of Seizure Clusters in Epilepsy: A Narrative Review on Rescue Therapies

Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study

Dispensary Cannabidiol (CBD): Nothing to Worry About!

Safety evaluation of perampanel as monotherapy or first adjunctive therapy in patients with epilepsy

Future opportunities for research in rescue treatments

Lack of clinically relevant differences in safety and pharmacokinetics after second‐dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis

Initial Real-World Experience With Cenobamate in Adolescents and Adults: A Single Center Experience

Use of second doses of Valtoco® (diazepam nasal spray) across 24 hours after the initial dose for out‐of‐hospital seizure clusters: Results from a phase 3, open‐label, repeat‐dose safety study

PROVE—Phase IV Study of Perampanel in Real-World Clinical Care of Patients with Epilepsy: Interim Analysis in Pediatric Patients

Collaborators (8)

Wendyl D'Souza

Anita N. Datta

Vikram R. Rao

Nitish Chourasia

Gregory Krauss

Clio Rubinos

Daniel Friedman

Antonietta Coppola

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