Jan Johannes Enghild

Professor

Aarhus University

Denmark

Research Interests

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About

Jan Johannes Enghild is a Professor at Aarhus Universitet in Denmark. His research encompasses various areas, including non-classical neutrophil extracellular traps, structural biology through cryo-EM, and the roles of specific proteins in disease mechanisms. His recent publications highlight his work on protease inhibition, corneal dystrophy, and interactions within the hyaluronan matrix, contributing to advancements in understanding cellular processes and disease pathology.

Articles (26)

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2025

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2021

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2021

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2021

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2020

Collaborators (19)

Annemarie Brüel

Aarhus University

DENMARK

Jan Johannes Enghild

Research Interests

Contact this professor

About

Articles (26)

The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring

TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery

Non-classical neutrophil extracellular traps induced by PAR2-signaling proteases

Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition

Young rat microbiota extracts strongly inhibit fibrillation of α-synuclein and protect neuroblastoma cells and zebrafish against α-synuclein toxicity

Mapping the Periostin splice isoforms in atopic dermatitis and an in vitro asthma model - A multi-platform analysis using mass spectrometry and RT-qPCR

Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1

Proteolytic cleavage of the TGFβ co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane

Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores

Development of a top-down MS assay for specific identification of human periostin isoforms

Chemical modification of hyaluronan oligosaccharides differentially modulates hyaluronan-hyaladherin interactions

Periostin Is a Disulfide-Bonded Homodimer and Forms a Complex with Fibronectin in the Human Skin

Periostin C-Terminal Is Intrinsically Disordered and Interacts with 143 Proteins in an In Vitro Epidermal Model of Atopic Dermatitis

Structural remodelling of the carbon–phosphorus lyase machinery by a dual ABC ATPase

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia

Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1

Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein

The low-density lipoprotein receptor-related protein 1 (LRP1) interactome in the human cornea

Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family

The last meal of Tollund Man: new analyses of his gut content

Development of selective protease inhibitors via engineering of the bait region of human α2-macroglobulin

Mutation-induced dimerization of transforming growth factor-β–induced protein may drive protein aggregation in granular corneal dystrophy

ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism

Substituting the Thiol Ester of Human A2M or C3 with a Disulfide Produces Native Proteins with Altered Proteolysis-Induced Conformational Changes

Collaborators (19)

Annemarie Brüel

Rasmus Kjeldsen Jensen

Philipp Kanis

Thomas Boesen

Florian Veillard

Nina Helt Nielsen

Rebecca Dodd

Anne Kruse Hollensen

Gregers Rom Andersen

Charles Blundell

Anokhi Shah

Colin Levy

József Dobó

Flavia Maria Sutera

Daniel E. Otzen

Anna Blom

Anthony Day

Ditlev Brodersen

Christian Damgaard

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