Jan Vondracek

professor

Czech Republic

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Jan Vondracek is a professor at Masarykova Univerzita Přírodovědecká Fakulta in the Czech Republic. His research focuses on the roles of the aryl hydrocarbon receptor in cancer therapy and metabolic processes, particularly in relation to lung cancer and colon health. Recent publications include studies on the disruption of sphingolipid profiles during epithelial-to-mesenchymal transition and the implication of environmental factors such as polycyclic aromatic hydrocarbons in cancer progression.

Articles (21)

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2025

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2021

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2020

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2020

Collaborators (19)

Amita Bansal

Research Fellow/Lecturer

Australian National University

AUSTRALIA

Jan Vondracek

Research Interests

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Articles (21)

Disruption of sphingolipid and glycosphingolipid profiles in human bronchial epithelial cells and extracellular vesicles during gradual benzo[a]pyrene-induced epithelial-to-mesenchymal transition

Emerging approaches for antagonizing the aryl hydrocarbon receptor

Aryl hydrocarbon receptor as a drug target in advanced prostate cancer therapy – obstacles and perspectives

Switching on/off aryl hydrocarbon receptor and pregnane X receptor activities by chemically modified tryptamines

Aryl hydrocarbon receptor (AhR) and pregnane X receptor (PXR) play both distinct and common roles in the regulation of colon homeostasis and intestinal carcinogenesis

Lung cancer associated with combustion particles and fine particulate matter (PM<sub>2.5</sub>) - The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR).

Benzo[b]naphtho[d]thiophenes and naphthylbenzo[b]thiophenes: Their aryl hydrocarbon receptor-mediated activities and environmental presence.

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors.

Obesity I: Overview and molecular and biochemical mechanisms.

Obesity II: Establishing causal links between chemical exposures and obesity

Aryl Hydrocarbon Receptor (AhR) Limits the Inflammatory Responses in Human Lung Adenocarcinoma A549 Cells via Interference with NF-κB Signaling

Inhibition of Aryl Hydrocarbon Receptor (AhR) Expression Disrupts Cell Proliferation and Alters Energy Metabolism and Fatty Acid Synthesis in Colon Cancer Cells

Macrophage-mediated tissue response evoked by subchronic inhalation of lead oxide nanoparticles is associated with the alteration of phospholipases C and cholesterol transporters

Role of miR-653 and miR-29c in downregulation of CYP1A2 expression in hepatocellular carcinoma.

In vitro profiling of toxic effects of environmental polycyclic aromatic hydrocarbons on nuclear receptor signaling, disruption of endogenous metabolism and induction of cellular stress

Deregulation of signaling pathways controlling cell survival and proliferation in cancer cells alters induction of cytochrome P450 family 1 enzymes

Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes

The Role of Metabolism in Toxicity of Polycyclic Aromatic Hydrocarbons and their Non-genotoxic Modes of Action

Complex Alterations of Fatty Acid Metabolism and Phospholipidome Uncovered in Isolated Colon Cancer Epithelial Cells

A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype.

Specific alterations of sphingolipid metabolism identified in EpCAM-positive cells isolated from human colon tumors

Collaborators (19)

Amita Bansal

Lenka Radova

Gerardo Vázquez

Petr Kysela

Francois BRION

Patrick Babin

Martina Hýžďalová

Jana Dumková

Pavel Babica

Jason Matthews

SAURABH CHATTERJEE

Min Ji kim

Christopher Kassotis

Anja Knoll-Gellida

Radim Vrzal

Sophie Langouet

Zdeněk Dvořák

Igor Kiss

Lisa Connolly

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