Jane Holmes

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University of Oxford

United Kingdom

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Recent Grants

Grant: Open

Optimising cultural expeRIences for mental health in underrepresented younG people onlINe (ORIGIN)

Open Date: 2023-05-01

Close Date: 2028-04-30

Grant: Close

A randomised controlled trial of TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation (TRANSLATE) of potential clinically significant prostate cancer

Open Date: 2021-04-01

Close Date: 2023-10-31

Grant: Close

A phase 1 trial of a retinoic acid receptor beta agonist for the treatment of spinal cord injury

Open Date: 2018-02-01

Close Date: 2021-09-29

Grant: Close

CRUK/17/015 CEDAR: Chemoradiation with Enadenotucirev as a radiosensitiser in locally advanced colorectal cancer

Open Date: 2017-10-01

Close Date: 2022-03-31

Articles (13)

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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UNITED KINGDOM

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Séan Micheal O'Cathail

University of Glasgow

UNITED KINGDOM

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Simon Royal

UNITED KINGDOM

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Jon Dickson

University of Sheffield

UNITED KINGDOM

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HANA HASSANIN

Associate Professor in Translational and Experimental Medicine and Director of Surrey Clinical Research Facility

University of Surrey

UNITED KINGDOM

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Mark Lown

University of Southampton

UNITED KINGDOM

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Victoria Homer

University of Birmingham

UNITED KINGDOM

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Alexander Ooms

University of Oxford

UNITED KINGDOM

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Timothy Stanley Maughan

Professor of Clinical Oncology, CRUK/MRC Oxford Institute for Radiation Oncology

University of Oxford

UNITED KINGDOM

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Azhar Zafar

Senior Lecturer

UNITED KINGDOM

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Vibhore Prasad

NIHR Senior Clinical Practitioner Research Award funded Clinical Associate Professor in Primary Care

University of Nottingham

UNITED KINGDOM

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Kerenza Hood

UNITED KINGDOM

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Haroon Ahmed

Senior Clinical Lecturer

Cardiff University

UNITED KINGDOM

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Najib M Rahman

Professor of Respiratory Medicine

University of Oxford

UNITED KINGDOM

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Jane Holmes

Research Interests

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Recent Grants

Articles (13)

Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in the UK PANORAMIC trial.

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease

Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-β agonist for treatment of spinal cord injury, in male healthy participants.

CHARIOT: a phase I study of berzosertib with chemoradiotherapy in oesophageal and other solid cancers using time to event continual reassessment method.

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial

Visualising harms in publications of randomised controlled trials: consensus and recommendations.

Effect of moderate to high intensity aerobic exercise on blood pressure in young adults: The TEPHRA open, two-arm, parallel superiority randomized clinical trial.

Early phase clinical trials extension to guidelines for the content of statistical analysis plans.

A multicentre retrospective review of SABR reirradiation in rectal cancer recurrence.

Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.

Randomised phase II trial of olaparib, chemotherapy or olaparib and cediranib in patients with platinum-resistant ovarian cancer (OCTOVA): a study protocol

A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar.

Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy oncology trials as examples.

Collaborators (18)

Chen Ji

Melissa Dobson

Philip Evans

Jienchi Dorward

Jonathan P. T. Corcoran

Séan Micheal O'Cathail

Simon Royal

Jon Dickson

HANA HASSANIN

Mark Lown

Victoria Homer

Alexander Ooms

Timothy Stanley Maughan

Azhar Zafar

Vibhore Prasad

Kerenza Hood

Haroon Ahmed

Najib M Rahman

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