Januario E. Castro, M.D.

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Professor of Medicine and Consultant

Mayo Clinic

United States

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About

Januario E. Castro, M.D. is a Professor of Medicine and Consultant at the Mayo Clinic in the United States. His research focuses primarily on innovative therapies for hematological malignancies, including Non-Hodgkin Lymphoma and Multiple Myeloma, as well as the implications of CAR T-cell therapy. Recent publications address critical issues such as clinical trial enrollment barriers, management of relapse in aggressive lymphomas, and neurotoxicity monitoring.

Recent Grants

Grant: Close

CART-PSMATGFBRDN-02: A Phase 1 Open-Label, Multicenter Study of PSMA Targeted Genetically Modified.

Open Date: 2020-11-01

Close Date: 2025-11-01

Grant: Close

A Phase I study of FT516 as monotherapy in relapsed/refractory acute yelogenous leukemia and in combination with monoclonal antibodies in relapsed/refractory B-cell lymphoma.

Open Date: 2020-04-01

Close Date: 2022-04-01

Grant: Close

FT-004 - Long-term follow-up study following treatment with Fate Therapeutics Engineered Cellular Immunotherapy.

Open Date: 2020-04-01

Close Date: 2025-04-01

Grant: Close

Phase I/II Study of Pembrolizumab in Combination with TG-1101 (Ublituximab) and TGR-1202 in Patients With Relapsed-refractory Chronic Lymphocytic Leukemia.

Open Date: 2016-06-01

Close Date: 2018-06-01

Grant: Close

A Phase I/Ib study evaluating the efficacy and safety of ublituximab, a third-generation anti-CD20 monoclonal antibody, in combination with TGR-1202

Open Date: 2016-06-01

Close Date: 2018-06-01

Articles (10)

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2022

Collaborators (1)

Matthew Maurer

Assistant Professor of Biostatistics and Medicine

Mayo Clinic Rochester

UNITED STATES

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Januario E. Castro, M.D.

Research Interests

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Contact this professor

About

Recent Grants

Articles (10)

Barriers to enrollment in clinical trials of patients with aggressive B-cell NHL that progressed after CAR T-cell therapy.

Response to COVID-19 Vaccination Post-CAR T Therapy in Patients With Non-Hodgkin Lymphoma and Multiple Myeloma.

Predictors and Management of Relapse to Axicabtagene Ciloleucel in Patients with Aggressive B-cell Lymphoma.

It Is in the Eye of the Beholder: Ocular Ultrasound Enhanced Monitoring of Neurotoxicity after CAR-T Cell Therapy.

Extracorporeal photopheresis for the treatment of chronic graft versus host disease.

Supportive Care for Patients with Lymphoma Undergoing CAR-T-cell Therapy: the Advanced Practice Provider's Perspective.

Acute seizures and status epilepticus in immune effector cell associated neurotoxicity syndrome (ICANS).

Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B.

Incidence of thrombosis in relapsed/refractory B-cell lymphoma treated with axicabtagene ciloleucel: Mayo Clinic experience.

Ibrutinib plus Obinutuzumab as Frontline Therapy for Chronic Lymphocytic Leukemia Is Associated with a Lower Rate of Infusion-Related Reactions and with Sustained Remissions after Ibrutinib Discontinuation: A Single-Arm, Open-Label, Phase 1b/2 Clinical Trial NCT0231576.

Collaborators (1)

Matthew Maurer

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