Jason Mears

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Assistant Professor

Case Western Reserve University School of Medicine

United States

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About

Dr. Jason Mears is an Assistant Professor at Case Western Reserve University School of Medicine in the United States. His research focuses on mitochondrial dynamics, bioenergetics, and the effects of disease-associated mutations on mitochondrial function. Recent articles by Dr. Mears explore topics such as the role of Fis1 in glioblastoma cells, high-resolution structural proteomics of mitochondria, and the impact of Drp1 mutations on mitochondrial machinery and metabolic programs.

Recent Grants

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Defining molecular interactions that drive mitochondrial fission

Open Date: 2018-02-01

Close Date: 2022-01-31

Grant: Close

Mitochondrial Dynamics in Brain TumorInitiating Cells

Open Date: 2017-09-01

Close Date: 2022-08-31

Grant: Close

The molecular mechanism of mitochondrial fission

Open Date: 2016-07-01

Close Date: 2018-06-01

Grant: Close

A mechanistic study of mitochondrial fission

Open Date: 2012-01-01

Close Date: 2015-12-01

Articles (13)

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2025

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2023

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2023

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2022

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2021

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2021

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2020

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2020

Collaborators (2)

Nicole Ducich

University of Maryland

UNITED STATES

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Joris Guyon

Associate Professor

Centre Hospitalier Universitaire Vaudois

FRANCE

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Jason Mears

Research Interests

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About

Recent Grants

Articles (13)

Conformational Rearrangement of Fission DSPs

Fis1 regulates mitochondrial morphology, bioenergetics and removal of mitochondrial DNA damage in irradiated glioblastoma cells

Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery

GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity.

DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs.

Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis.

High-Resolution Structural Proteomics of Mitochondria Using the ‘Build and Retrieve’ Methodology

Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division.

Solvent accessibility of E1α and E1β residues with known missense mutations causing pyruvate dehydrogenase complex (PDC) deficiency: Impact on PDC-E1 structure and function.

Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass.

A structure and function relationship study to identify the impact of the R721G mutation in the human mitochondrial lon protease.

GFP fluorescence tagging alters dynamin-related protein 1 oligomerization dynamics and creates disassembly-refractory puncta to mediate mitochondrial fission.

Affinity Purification and Functional Characterization of Dynamin-Related Protein 1.

Collaborators (2)

Nicole Ducich

Joris Guyon

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