Jean-Francois Desaphy

Associate Professor of Pharmacology

University of Bari Aldo Moro

Italy

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Jean-Francois Desaphy is an Associate Professor of Pharmacology at Università degli Studi di Bari Aldo Moro, Italy. His research areas include the pharmacological protection of the esophageal mucosa, immunoglobulin therapy in multiple myeloma management, and the genetic implications of sodium channel mutations on cardiac and muscular function. He has contributed significantly to the understanding of how cellular structures respond to gravitational changes and the effects of extracellular vesicles in bone marrow endothelial cells.

Jean-Francois Desaphy

Research Interests

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Articles (18)

Poliprotect®, a Medical Device Made of Substances, Potently Protects the Human Esophageal Mucosa Challenged by Multiple Agents: Evidence from In Vitro and Ex Vivo Electrophysiological Models

Immunoglobulin Replacement Therapy: Insights into Multiple Myeloma Management

How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Missense and Non-Missense Lamin A/C Gene Mutations Are Similarly Associated with Major Arrhythmic Cardiac Events: A 20-Year Single-Centre Experience

A c.1775C &gt; T Point Mutation of Sodium Channel Alfa Subunit Gene (SCN4A) in a Three-Generation Sardinian Family with Sodium Channel Myotonia

Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels

Uptake-Dependent and -Independent Effects of Fibroblasts-Derived Extracellular Vesicles on Bone Marrow Endothelial Cells from Patients with Multiple Myeloma: Therapeutic and Clinical Implications

ECM Composition Differentially Regulates Intracellular and Extracellular pH in Normal and Cancer Pancreatic Duct Epithelial Cells

Anti-Angiogenic Activity of Drugs in Multiple Myeloma

Drug repurposing in skeletal muscle ion channelopathies

How do gravity alterations affect animal and human systems at a cellular/tissue level?

Coexistence of SCN4A and CLCN1 mutations in a family with atypical myotonic features: A clinical and functional study

Target Mutation-Driven Drug Discovery

Ion Channels in Multiple Myeloma: Pathogenic Role and Therapeutic Perspectives

The Landscape of lncRNAs in Multiple Myeloma: Implications in the &ldquo;Hallmarks of Cancer&rdquo;, Clinical Perspectives and Therapeutic Opportunities

Ion Channel Involvement in Tumor Drug Resistance

Using occurrence data to evaluate extinction reveals a strong resilience of butterflies in a National Park of Southern Europe (Alta Murgia National Park)

Ion Channel Gene Mutations Causing Skeletal Muscle Disorders: Pathomechanisms and Opportunities for Therapy

Collaborators (15)

Angelo Vacca

Alain GUIGNANDON

Rocco Labadessa

Roberto Ria

Daniela Grimm

Grazia Tamma

Nicoletta Resta

Vanessa Desantis

Clelia Tiziana Storlazzi

Ronnie Willaert

ANTONIO GIOVANNI SOLIMANDO

Stephan Reshkin

Rosa Angela Cardone

Maria Maddalena Cavalluzzi

Kevin Tabury

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A c.1775C > T Point Mutation of Sodium Channel Alfa Subunit Gene (SCN4A) in a Three-Generation Sardinian Family with Sodium Channel Myotonia

The Landscape of lncRNAs in Multiple Myeloma: Implications in the “Hallmarks of Cancer”, Clinical Perspectives and Therapeutic Opportunities