Jean Luc Bourrain

Background Allergic contact dermatitis (ACD) and photoallergic contact dermatitis (PACD) to benzophenone present in printing ink have been reported. However, precise chemical analyses and extended photo‐patch tests have not been performed in these cases. Objectives To determine which components present in a magazine cover are responsible for a patient's skin reaction, to determine the primary sensitizer, and precisely diagnose ACD and PACD. Methods After initial photo‐patch tests were performed on a patient with a history of reaction to magazine covers after sun exposure, gas chromatography–mass spectrometry and high‐performance liquid chromatography analyses of the magazine covers, and additional photo‐patch tests were performed. Results The first photo‐patch test results confirmed PACD to ketoprofen and fenofibrate and evoked PACD to the magazine covers. 4‐methyl benzophenone (4‐MBP) and 1‐hydroxy‐cyclohexyl‐phenyl‐ketone (1‐HCPK) were found in the magazine cover. Additional photo‐patch tests confirmed PACD to 1‐HCPK and to benzophenone, and photo‐aggravated ACD to 4‐MBP. The primary sensitizer was ketoprofen. Conclusions Benzophenones are present in a wide variety of products, without always being listed on the packaging. Patients previously sensitized to other ketones, such as ketoprofen, may react to benzophenones without being able to avoid contact with these molecules. New regulations may be needed for more efficient eviction advice.