Jean-Michel CHEZAL

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Professeur des Universités

Université Clermont Auvergne

France

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About

Jean-Michel CHEZAL is a Professeur des Universités at Université Clermont Auvergne in France. His research focuses on the development of radiotracers for PET imaging, antibody-drug conjugates for cancer treatment, and novel therapeutic approaches for advanced solid tumors. Recent work includes the synthesis and evaluation of various chelators for immunoconjugates and targeted radionuclide therapies. His contributions provide significant advancements in the fields of medicinal chemistry and oncology.

Recent Grants

Grant: Close

Targeted radionuclide therapy of melanoma

Open Date: 2012-09-03

Close Date: 2015-09-03

Articles (13)

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2024

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2023

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2022

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2022

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2022

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2020

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2020

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2020

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2020

Collaborators (10)

Emmanuel Moreau

assitant professor

Université Clermont Auvergne

FRANCE

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Vincent Gaumet

Professeur

Université Clermont Auvergne

FRANCE

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Sébastien Fortin

Laval University

CANADA

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florent cachin

Head/MD, PhD

FRANCE

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Damien Boyer

Université Clermont Auvergne

FRANCE

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Benjamin Gibert

FRANCE

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Mercedes Quintana

Université Clermont Auvergne

FRANCE

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Barbara Wenzel

GERMANY

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Caroline PEYRODE

FRANCE

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Nicolas SAS

UMR 1240 Inserm/UCA

FRANCE

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Jean-Michel CHEZAL

Research Interests

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About

Recent Grants

Articles (13)

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

Branched pegylated linker-auristatin to control hydrophobicity for the production of homogeneous minibody-drug conjugate against HER2-positive breast cancer

From netrin‐1‐targeted <scp>SPECT</scp> / <scp>CT</scp> to internal radiotherapy for management of advanced solid tumors

Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes

Synthesis and In Vitro Comparison of DOTA, NODAGA and 15-5 Macrocycles as Chelators for the <sup>64</sup>Cu-Labelling of Immunoconjugates

Novel Radioiodinated and Radiofluorinated Analogues of FT-2102 for SPECT or PET Imaging of mIDH1 Mutant Tumours

A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs

Phase I study of [131I] ICF01012, a targeted radionuclide therapy, in metastatic melanoma: MELRIV-1 protocol

Synthesis and in vitro preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer

Optimization of IEDDA bioorthogonal system: Efficient process to improve trans-cyclooctene/tetrazine interaction

Relevance of the combination of external beam radiotherapy with the hypoxia-activated prodrug ICF05016 in an experimental model of extraskeletal myxoid chondrosarcoma

Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapy

[18F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer

Collaborators (10)

Emmanuel Moreau

Vincent Gaumet

Sébastien Fortin

florent cachin

Damien Boyer

Benjamin Gibert

Mercedes Quintana

Barbara Wenzel

Caroline PEYRODE

Nicolas SAS

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