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Jean-Michel CHEZAL

Professeur des Universités

Université Clermont Auvergne

France

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Research Interests

Medical Imaging

20%

Pharmacology

60%

Radiopharmaceutical Chemistry

50%

Cancer Therapy

30%

Molecular Imaging

30%

Pet Imaging

30%

Radiation Therapy

30%

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Recent Grants

Grant: Close

Targeted radionuclide therapy of melanoma

Open Date: 2012-09-03

Close Date: 2015-09-03

Articles13

Improved automated one-pot two-step radiosynthesis of (S)-[18F]FETrp, a radiotracer for PET imaging of indoleamine 2,3-dioxygenase 1 (IDO1)

Article Link

Year:

2024

Branched pegylated linker-auristatin to control hydrophobicity for the production of homogeneous minibody-drug conjugate against HER2-positive breast cancer

Article Link

Year:

2024

From netrin‐1‐targeted <scp>SPECT</scp> / <scp>CT</scp> to internal radiotherapy for management of advanced solid tumors

Article Link

Year:

2023

Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes

Article Link

Year:

2023

Synthesis and In Vitro Comparison of DOTA, NODAGA and 15-5 Macrocycles as Chelators for the <sup>64</sup>Cu-Labelling of Immunoconjugates

Article Link

Year:

2022

Novel Radioiodinated and Radiofluorinated Analogues of FT-2102 for SPECT or PET Imaging of mIDH1 Mutant Tumours

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Year:

2022

A Convenient Route to New (Radio)Fluorinated and (Radio)Iodinated Cyclic Tyrosine Analogs

Article Link

Year:

2022

Phase I study of [131I] ICF01012, a targeted radionuclide therapy, in metastatic melanoma: MELRIV-1 protocol

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Year:

2022

Synthesis and in vitro preliminary evaluation of prostate-specific membrane antigen targeted upconversion nanoparticles as a first step towards radio/fluorescence-guided surgery of prostate cancer

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Year:

2021

Optimization of IEDDA bioorthogonal system: Efficient process to improve trans-cyclooctene/tetrazine interaction

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Year:

2020

Relevance of the combination of external beam radiotherapy with the hypoxia-activated prodrug ICF05016 in an experimental model of extraskeletal myxoid chondrosarcoma

Article Link

Year:

2020

Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapy

Article Link

Year:

2020

[18F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer

Article Link

Year:

2020

Collaborators10

Emmanuel Moreau

assitant professor

Université Clermont Auvergne

FRANCE

Vincent Gaumet

Professeur

Université Clermont Auvergne

FRANCE

Sébastien Fortin

Laval University

CANADA

florent cachin

Head/MD, PhD

FRANCE

Damien Boyer

Université Clermont Auvergne

FRANCE

Benjamin Gibert

FRANCE

Mercedes Quintana

Université Clermont Auvergne

FRANCE

Barbara Wenzel

GERMANY

Caroline PEYRODE

FRANCE

Nicolas SAS

UMR 1240 Inserm/UCA

FRANCE

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