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Jean Sévigny

Senior Scientist

Université Laval

Canada

Research Interests

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Professors in Canada Professors in Cell Biology Cell Biology professors in Canada

About

Jean Sévigny is a Professor at Université Laval in Canada. His research focuses on the design and synthesis of inhibitors targeting ectonucleotidases, with recent studies exploring novel derivatives of nalidixic acid and thiosemicarbazones. Additionally, he has investigated the structural modeling of NTPDase-substrate complexes and the immunomodulatory functions of ectonucleotidases in various biological contexts.

Articles (14)

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2024

Collaborators (3)

Seung Kim

KM Mulberry Professor

Stanford University

UNITED STATES

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Muhammad Safwan Akram

Professor

Teesside University

UNITED KINGDOM

View details

Tajamul Hussain

Research Associate

University of Florida

UNITED STATES

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Jean Sévigny

Research Interests

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About

Articles (14)

Halogen‐Substituted Thiourea Derivatives as CD73 Inhibitors: In Vitro and In Silico Studies

Quinoline carboxylic acid derivatives as inhibitors of NPPs: Synthesis, in silico and in vitro evaluation

P2Y2 Receptor Controls TLR3‐Induced Chemokine Production in Intestinal Epithelial Cells

Design, synthesis and in vitro and evaluation of novel nalidixic acid derivatives as potent ectonucleotidases inhibitors

Structural Modeling of NTPDase-Substrate Complexes Preserving Catalytic Experimental Features

Synthesis, Biological Evaluation and Molecular Docking Studies of Novel 4‐Propylsulfonylpiperazines‐Based Thiosemicarbazones as Ecto‐5′‐Nucleotidase and NTPDase Inhibitors

Assessing Ecto-5’-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cells

Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphate

P2Y2 Receptor Signaling in Health and Disease

CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets

Endometrial epithelial cell organoids as tools for studying the CD39 family of enzymes and for validating enzyme inhibitors.

Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.

Extracellular nucleotides in smooth muscle contraction

Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitors

Collaborators (3)

Seung Kim

Muhammad Safwan Akram

Tajamul Hussain

Make your next move.

Jean Sévigny

Research Interests

Make your next move.

Explore related searches

About

Articles (14)

Halogen‐Substituted Thiourea Derivatives as CD73 Inhibitors: In Vitro and In Silico Studies

Quinoline carboxylic acid derivatives as inhibitors of NPPs: Synthesis, in silico and in vitro evaluation

P2Y2 Receptor Controls TLR3‐Induced Chemokine Production in Intestinal Epithelial Cells

Design, synthesis and in vitro and evaluation of novel nalidixic acid derivatives as potent ectonucleotidases inhibitors

Structural Modeling of NTPDase-Substrate Complexes Preserving Catalytic Experimental Features

Synthesis, Biological Evaluation and Molecular Docking Studies of Novel 4‐Propylsulfonylpiperazines‐Based Thiosemicarbazones as Ecto‐5′‐Nucleotidase and NTPDase Inhibitors

Assessing Ecto-5’-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cells

Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphate

P2Y2 Receptor Signaling in Health and Disease

CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic &amp; regulatory functions against human islets

Endometrial epithelial cell organoids as tools for studying the CD39 family of enzymes and for validating enzyme inhibitors.

Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and -3 inhibitors.

Extracellular nucleotides in smooth muscle contraction

Design, synthesis and in vitro evaluation of novel sulfonylurea and sulfonylthiourea as ectonucleotidases inhibitors

Collaborators (3)

Seung Kim

Muhammad Safwan Akram

Tajamul Hussain

Make your next move.

CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets