Jeanine F. Amacher

Western Washington University

United States

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Articles (14)

Year:

2025

Vogel et al. reveals the stereochemical basis of alternative substrate cleavage by S. pyogenes SrtA for ligands with a P1′ Leu residue. The substrate adopts puckered alternative binding, whereby cleavage occurs between the P1′ and P2′ positions.

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2022

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2022

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2022

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2022

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2021

Year:

2020

Collaborators (1)

Susan Marqusee

Professor

University of California, Berkeley

UNITED STATES

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Jeanine F. Amacher

Research Interests

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Articles (14)

Substrate recognition in Bacillus anthracis sortase B beyond its canonical pentapeptide binding motif and use in sortase-mediated ligation.

A unique binding mode of P1′ Leu-containing target sequences for <i>Streptococcus pyogenes</i> sortase A results in alternative cleavage

The conformation of the nSrc specificity-determining loop in the Src SH3 domain is modulated by a WX conserved sequence motif found in SH3 domains.

Amino acid variability at W194 of Staphylococcus aureus sortase A alters nucleophile specificity

Sortases: structure, mechanism, and implications for protein engineering

A unique binding mode of P1′ Leu-containing target sequences for Streptococcus pyogenes sortase A results in alternative cleavage

An idea to explore: Engaging high school students in structure‐function studies of bacterial sortase enzymes and inhibitors ‐ A comprehensive computational experimental pipeline

Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets.

Saturation mutagenesis of a predicted ancestral Syk‐family kinase

Comparative Analysis and Ancestral Sequence Reconstruction of Bacterial Sortase Family Proteins Generates Functional Ancestral Mutants with Different Sequence Specificities

Structural and biochemical analyses of selectivity determinants in chimeric Streptococcus Class A sortase enzymes

Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition.

Domain Analysis and Motif Matcher (DAMM): A Program to Predict Selectivity Determinants in Monosiga brevicollis PDZ Domains Using Human PDZ Data

Specificity in PDZ-peptide interaction networks: Computational analysis and review

Collaborators (1)

Susan Marqusee

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