Jed Lampe

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Assistant Professor

University of Colorado Denver School of Pharmacy

United States

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Recent Grants

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Perfluoroalkanoate (PFAS) modulation of the inflammatory response through potent inhibition of arachidonic acid metabolizing cyclooxygenase and cytochrome P450 enzymes

Open Date: 2021-12-01

Close Date: 2023-11-30

Grant: Close

The role of CYP3A7 in the disposition and toxicity of HIV inhibitors in the developing infant

Open Date: 2018-08-01

Close Date: 2023-05-31

Grant: Close

The role of CYP3A7 in the disposition and toxicity of HIV inhibitors in the developing infant

Open Date: 2018-08-01

Close Date: 2023-05-31

Articles (12)

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2021

Year:

2021

Collaborators (3)

Weng-Lang Yang

Research Professor

Albert Einstein College of Medicine

UNITED STATES

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John Hackett

Professor

Florida International University

UNITED STATES

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Juan Pablo Idrovo

Assistant Professor of Surgery and Critical Care

University of Colorado Health

UNITED STATES

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Jed Lampe

Research Interests

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Recent Grants

Articles (12)

Drug metabolism of ciprofloxacin, ivacaftor, and raloxifene by Pseudomonas aeruginosa cytochrome P450 CYP107S1

HCV Antiviral Drugs Have the Potential to Adversely Perturb the Fetal-Maternal Communication Axis through Inhibition of CYP3A7 DHEA-S Oxidation

Comparison of the CYP3A selective inhibitors CYP3cide, clobetasol, and azamulin for their potential to distinguish CYP3A7 activity in the presence of CYP3A4/5

Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate

Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims

Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach

Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement.

Pseudomonas aeruginosa cytochrome P450 CYP168A1 is a fatty acid hydroxylase that metabolizes arachidonic acid to the vasodilator 19-HETE

Cefadroxil Comparable to Cephalexin: Minimum Inhibitory Concentrations among Methicillin-Susceptible Staphylococcus aureus Isolates from Pediatric Musculoskeletal Infections.

Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (M<sup>pro</sup>) inhibitors.

Characterization of fluorescent probe substrates to develop an efficient high-throughput assay for neonatal hepatic CYP3A7 inhibition screening.

Inhibition of CYP3A7 DHEA-S Oxidation by Lopinavir and Ritonavir: An Alternative Mechanism for Adrenal Impairment in HIV Antiretroviral-Treated Neonates

Collaborators (3)

Weng-Lang Yang

John Hackett

Juan Pablo Idrovo

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