Jeffery Kelly

Lita Annenberg Hazen Professor of Chemistry

Scripps Research Institute

United States

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Jeffery Kelly is the Lita Annenberg Hazen Professor of Chemistry at The Scripps Research Institute in the United States. His research primarily focuses on protein misfolding diseases, amyloidogenic proteins, and the pharmacological activation of proteostasis networks. Recent articles authored by him delve into various aspects such as transthyretin stabilization, biomarker development for ATTR polyneuropathy, and the impact of A-Synuclein on synaptic integrity.

Articles (10)

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (4)

Yvonne Eisele

Assistant Professor

University of Pittsburgh

UNITED STATES

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Tingwei Mu

Associate Professor

Case Western Reserve University School of Medicine

UNITED STATES

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Luke Wiseman

Professor

Scripps Research Institute

UNITED STATES

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Fabrizio Chiti

University of Florence

ITALY

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Jeffery Kelly

Research Interests

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Articles (10)

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site

Analysis of lumbar spine stenosis specimens for identification of amyloid

Characterising diflunisal as a transthyretin kinetic stabilizer at relevant concentrations in human plasma using subunit exchange

Inverse Drug Discovery identifies weak electrophiles affording protein conjugates

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA<sub>A</sub> receptors

Small molecule protein binding to correct cellular folding or stabilize the native state against misfolding and aggregation

Tafamidis polyneuropathy amelioration requires modest increases in transthyretin stability even though increases in plasma native TTR and decreases in non-native TTR do not predict response

A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction

A-Synuclein oligomers induce glutamate release from astrocytes and excessive extrasynaptic nmdar activity in neurons, thus contributing to synapse loss

Collaborators (4)

Yvonne Eisele

Tingwei Mu

Luke Wiseman

Fabrizio Chiti

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