Jeffrey Holden

Head of Structural Biology

United States

Research Interests

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About

Jeffrey Holden is the Head of Structural Biology at Vilya, located in the United States. His research primarily focuses on structural biology, with recent publications addressing protein inhibitors, the optimization of homology-directed repair, and allosteric inhibition mechanisms. Additionally, he explores computational methods for studying protein-peptide interactions and the regulation of important signaling pathways.

Articles (6)

Year:

2025

Year:

2024

Year:

2022

Year:

2022

Year:

2022

Year:

2020

Collaborators (1)

Craig Ennis

Senior Scientist

University of California, San Francisco

UNITED STATES

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Jeffrey Holden

Research Interests

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Articles (6)

Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7.

Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair.

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.

Computational Site Saturation Mutagenesis of Canonical and Non-Canonical Amino Acids to Probe Protein-Peptide Interactions.

Incorporating NOE-Derived Distances in Conformer Generation of Cyclic Peptides with Distance Geometry.

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

Collaborators (1)

Craig Ennis

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