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Jeffrey L. Garvin
Has grant
Senior Scientist
United StatesResearch Interests
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Recent Grants
Grant: Open
KUH-TN Training Core
Open Date: 2021-09-15
Close Date: 2031-06-30
Grant: Close
The role of the proximal nephron in salt-sensitive hypertension
Open Date: 2016-01-01
Close Date: 2025-06-30
Grant: Close
Blood Pressure Regulation: Novel Roles for the Kidney
Open Date: 2009-04-01
Close Date: 2015-12-31
Grant: Close
Renal NO synthase & blood pressure
Open Date: 2008-06-01
Close Date: 2009-03-31
Grant: Open
Salt-Sensitive Hypertension: Role of renal superoxide
Open Date: 2002-09-01
Close Date: 2029-04-30
Articles (4)
Year:
2026
Year:
2025
Year:
2025
A diet containing amounts of fructose consumed by 17 million Americans causes salt-sensitive hypertension. Oxidative stress is an initiating cause of this model of fructose-induced salt-sensitive hypertension increasing blood pressure. This salt-sensitive hypertension is prevented by losartan and thus is angiotensin II (ANG II) dependent. Fructose-induced salt-sensitive hypertension depends on ANG II stimulating oxidative stress in the proximal tubule. A fructose/high-salt diet augments the ability of ANG II to stimulate proximal tubule O 2 − via protein kinase C.
Year:
2024
Collaborators (6)
Jinsook Son
Assistant Professor
Weill Cornell Medicine
Beau Forester
NorthShore University HealthSystem
Ora A. Weisz
University of Pittsburgh School of Medicine
Jeffrey Schelling
Professor
Case Western Reserve University
Ivy Samuels
Project Staff Scientist
Cleveland Clinic Foundation
Agustin Gonzalez-Vicente
Assistant Professor
Case Western Reserve University School of Medicine
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