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Jeffrey Wade Harper

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Chair

Harvard University

United States

Research Interests

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Recent Grants

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Mechanisms overwhelming protein and organelle quality control in Parkinson’s Disease

Open Date: 2020-09-01

Close Date: 2023-09-01

Grant: Close

A quantitative framework for understanding endosomal trafficking networks in Alzheimer's disease

Open Date: 2018-09-30

Close Date: 2023-08-31

Grant: Close

Systematic discovery and functional analysis of the PARKIN modified proteome

Open Date: 2013-09-25

Close Date: 2020-06-30

Grant: Close

Systematic Exploration of the Human Interactome

Open Date: 2012-08-21

Close Date: 2022-06-30

Grant: Close

Mechanisms of Selective Autophagy

Open Date: 2011-07-01

Close Date: 2020-03-31

Articles (18)

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Collaborators (3)

Brenda Schulman

Director

Max Planck Institute of Biochemistry

GERMANY

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Eric S. Fischer

Director

Harvard Medical School

UNITED STATES

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Sichen Shao

Associate Professor

Harvard Medical School

UNITED STATES

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Jeffrey Wade Harper

Research Interests

Explore related searches

Recent Grants

Articles (18)

Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion

Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST

ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution

GFP-YIPF3 Immunoprecipitation V2

Cell lysis and immunoblotting

Flow cytometry-based measurement of trafficking of Golgi to the lysosome via autophagy V3

Gene editing of YIPF3, YIPF4, CALCOCO1, FIP200, and ATG7 in HEK293 and HeLa cells V2

Gene editing of YIPF4 in hESCs V3

Proximity biotinylation of ATG8 proteins and selective autophagy receptors V2

mCherry-YIPF4 Immunoprecipitation V2

Combinatorial selective ER-phagy remodels the ER during neurogenesis

Electroporation of Cas9 protein into human pluripotent stem cells

Neural differentiation of AAVS1-TRE3G-NGN2 pluripotent stem cells

Neural differentiation on EM grids - iNeurons sample preparation for cryo-ET and CLEM V2

Endogenous tagging of the YIPF4 gene with mNEON Green and imaging of these cells by microscopy v2

Analysis of ER structures in Cultured Induced Neuron axons

Characterizing spatial and temporal properties of ER-phagy receptors

Analysis of ER Flux in Cultured Induced Neurons using Keima ER reporters

Collaborators (3)

Brenda Schulman

Eric S. Fischer

Sichen Shao

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