Jerzy Mozrzymas

full professor

Medical University of Silesia

Poland

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About

Jerzy Mozrzymas is a full professor at Wrocław Medical University in Poland. His research focuses on GABAergic plasticity and synaptic mechanisms within the hippocampus, as evidenced by his recent publications on extracellular matrix integrity and GABAA receptor gating. He investigates the roles of neurotransmitter systems and integrins in modulating synaptic transmission and plasticity.

Articles (17)

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2021

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2021

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2021

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2020

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2020

Collaborators (2)

Katarzyna Lebida

Wroclaw Medical University

POLAND

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Anna Andrzejczak

Ludwik Hirszfeld Institute of Immunology and Experimental Therapy

POLAND

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Jerzy Mozrzymas

Research Interests

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Articles (17)

Extracellular matrix integrity regulates GABAergic plasticity in the hippocampus

Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons

GABAergic synapses onto SST and PV interneurons in the CA1 hippocampal region show cell-specific and integrin-dependent plasticity

Mutation of valine 53 at the interface between extracellular and transmembrane domains of the β2 principal subunit affects the GABAA receptor gating

GABAA receptor proline 273 at the interdomain interface of the β2 subunit regulates entry into desensitization and opening/closing transitions

Integrins bidirectionally regulate the efficacy of inhibitory synaptic transmission and control GABAergic plasticity

α<sub>1</sub> proline 277 residues regulate GABA<sub>A</sub>R gating through M2-M3 loop interaction in the interface region

Interaction between GABAA receptor α1 and β2 subunits at the N-terminal peripheral regions is crucial for receptor binding and gating

Glycine substitution of α1F64 residue at the loop D of GABAA receptor impairs gating – Implications for importance of binding site-channel gate linker rigidity

Extracellular metalloproteinases in the plasticity of excitatory and inhibitory synapses

Induction of inhibitory synaptic plasticity enhances tonic current by increasing the content of α5-subunit containing GABA<sub>A</sub> receptors in hippocampal pyramidal neurons

Long-term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3

Mutations at the M2 and M3 transmembrane helices of the GABA<sub>A</sub> Rsα<sub>1</sub> and β<sub>2</sub> subunits affect primarily late gating transitions including opening/closing and desensitization

The β2 subunit E155 residue as a proton sensor at the binding site on GABA type A receptors

α<sub>1</sub> subunit histidine 55 at the interface between extracellular and transmembrane domains affects preactivation and desensitization of the GABA<sub>A</sub> receptor

GABA<sub>A</sub> receptor β<sub>2</sub>E155 residue located at the agonist-binding site is involved in the receptor gating

Mutations of α<sub>1</sub>F45 residue of GABA<sub>A</sub> receptor loop G reveal its involvement in agonist binding and channel opening/closing transitions

Collaborators (2)

Katarzyna Lebida

Anna Andrzejczak

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