Jette Lengefeld

This postdoctoral position at Karolinska Institutet offers an exciting opportunity to investigate how metabolism shapes stem cell aging, with a focus on hematopoietic stem cells and their role in tissue regeneration and healthspan extension. The project is funded by Novo Nordisk and the Swedish Research Council Starting Grant, ensuring robust financial support and access to state-of-the-art research facilities. The research will be conducted in the NEO research hub at the Flemingsberg campus, within an international and interdisciplinary environment that encourages collaboration and innovation. As a member of Dr. Jette Lengefeld’s team, you will explore the metabolic factors driving stem cell aging using advanced techniques such as flow cytometry, RNA/DNA sequencing, proteomics, metabolomics, immunofluorescence microscopy, and hematopoietic stem cell transplantation. The lab is part of the Center for Hematology and Regenerative Medicine (HERM) and the Department of Medicine, Huddinge, providing access to core facilities for cell sorting, microscopy, sequencing, mouse models, and clinical samples. The position is full-time, initially for two years with the possibility of extension for up to two additional years. You will benefit from Karolinska Institutet’s collective agreement, which includes state university benefits. The research environment is creative and inspiring, with opportunities to interact with leading scientists across medical and biological disciplines. The university is renowned for its medical research and education, fostering groundbreaking collaborations and a close relationship with healthcare providers. Applicants must have a PhD in hematology, hematopoietic stem cell biology, aging biology, or a related field, or a foreign degree equivalent to a Swedish PhD. Essential requirements include at least one first-author publication in a peer-reviewed journal, strong expertise in working with mice, Laboratory Animal Science certification, excellent English communication skills, strong analytical abilities, and familiarity with data analysis tools. Completion of the doctoral degree within the last three years is advantageous. Desirable skills include hands-on experience with advanced flow cytometry, a background in experimental stem cell biology and hematology, teamwork and communication skills, logical biological thinking, and expertise in R and statistics. To apply, submit your application via the Varbi recruitment system by 15 May 2026. Required documents include a complete CV (maximum one page), a short publication list, positions held, awards and prizes, and a link to your Google Scholar profile. All documents must be in English. Do not apply via email. For further information, contact Dr. Jette Lengefeld or the HR-Partner Anna Heinerö. Union representatives are also available for support. This position is ideal for highly motivated researchers seeking to advance their careers in stem cell biology, metabolism, and aging within a world-leading medical university. Join Karolinska Institutet and contribute to better health for all through innovative research.

Jette Lengefeld’s lab is advertising a Postdoctoral Researcher opening at Karolinska Institutet for research on healthy aging , stem cell aging , cellular enlargement , and stem cell function and metabolism . The lab’s research focuses on how stem cells age, how cell size affects function, and how these mechanisms may be used to maintain tissue health and prevent disease. The project is centered on hematopoietic (blood) stem cells and uses approaches such as molecular profiling and mouse models to identify pathways that drive stem cell dysfunction during aging, to explore rejuvenation strategies, and to study whether dysregulation of stem cell size contributes to cancer/leukemia. The post is based in a collaborative environment spanning Karolinska Institutet and the University of Helsinki . The lab notes support from multiple funders, including the Novo Nordisk Foundation , and indicates that the position is part of an active research program in aging biology and biomedical science. Deadline: 2026-05-15. Interested candidates should use the lab website to access the open position/application portal and apply directly through the linked recruitment system. Research keywords: stem cell aging, healthy aging, cellular enlargement, metabolism, hematopoietic stem cells, molecular profiling, mouse models, leukemia, aging biology.

Join the Lengefeld Lab at Karolinska Institutet for a postdoctoral position focused on the intersection of metabolism, aging, and stem cell biology. This Novo Nordisk-funded project aims to unravel how stem cell metabolism contributes to aging and the decline in tissue regeneration, a major health issue as populations live longer. The research will investigate rejuvenation of the blood system and its impact on systemic metabolic functions, with the goal of restoring cellular functions and extending healthspan. As a postdoctoral researcher, you will work under the guidance of Assistant Professor Dr. Jette Lengefeld in a modern research hub (NEO) at Karolinska Institutet, Huddinge. The lab is part of the Center for Hematology and Regenerative Medicine (HERM) and the Department of Medicine. You will join an international, interdisciplinary team with access to state-of-the-art core facilities, including cell sorting, microscopy, sequencing, mouse facilities, and clinical samples. The position is supported by the prestigious Swedish Research Council Starting Grant and offers a creative, inspiring environment with wide-ranging expertise and collaborative opportunities. Your project will utilize hematopoietic stem cells from mice to identify metabolic factors driving stem cell aging. Techniques include flow cytometry, RNA/DNA sequencing, proteomics, metabolomics, immunofluorescence microscopy, HSC transplantation, and multi-organ assays. The appointment is for two years, with possible extension for up to two additional years, and comes with a monthly salary and state university benefits. Applicants must have a PhD in hematology, hematopoietic stem cell biology, aging biology, or a related field, with at least one first-author publication in a peer-reviewed journal. Strong expertise in working with mice and Laboratory Animal Science certification are required. Additional desirable skills include advanced flow cytometry, experimental stem cell biology, teamwork, research communication, logical thinking in biological terms, and proficiency in R and statistics. Excellent English communication and analytical skills are essential. Eligibility requires a PhD or equivalent foreign degree, preferably completed within the last three years, though earlier completion may be considered for special reasons. Karolinska Institutet is one of the world's leading medical universities, offering successful medical research and the largest range of medical education in Sweden. The university fosters crossover collaborations and maintains close relationships with healthcare providers, ensuring top-quality education and research. Employees benefit from collective agreements and a supportive academic environment. To apply, submit your application through the Varbi recruitment system by 15 May 2026. Include a complete CV (max 1 page), short publication list, positions held, awards, prizes, and a link to your Google Scholar profile. Do not apply via email. For more information, visit the supervisor's academic page or the application portal. Make a difference in aging research and contribute to better health for all at Karolinska Institutet!

Karolinska Institutet is advertising a postdoc position in the Lengefeld lab focused on healthy aging , stem cell aging , and the biology of cellular enlargement . The lab studies how stem cells lose function during aging and how this contributes to tissue deterioration and disease. The research is centered on blood/hematopoietic stem cells and combines molecular profiling, mouse models, and mechanistic studies of metabolism and stem cell fitness. The lab is led by Jette Lengefeld , Assistant Professor at the University of Helsinki and Karolinska Institutet. The group works across two locations: the University of Helsinki and Karolinska Institutet. The post is part of a broader research program supported by major funders including the Novo Nordisk Foundation, the European Research Council, the Swedish Research Council, and the Research Council of Finland. Research themes mentioned on the lab site include: identifying pathways that drive stem cell dysfunction during enlargement, rejuvenating stem cells by preventing enlargement, and investigating whether dysregulation of stem cell size promotes cancer/leukemia. This makes the opportunity especially relevant for candidates interested in biology , medical science , aging biology, stem cell metabolism, and translational biomedical research. The lab states that it is hiring 1 Postdoc and provides an application link through the Karolinska Institutet job portal. The deadline shown on the lab website is 27 August 2026 . Applicants should review the linked posting for the full application instructions and required materials.

Karolinska Institutet is advertising a Postdoctoral Researcher position in metabolism, aging and stem cell biology in the research group of Assistant Professor Dr. Jette Lengefeld . The project addresses a major biological and medical question: how stem cell metabolism changes with age and how these metabolic shifts contribute to the loss of tissue regeneration and declining health later in life. The project is Novo Nordisk-funded and also supported by the Swedish Research Council Starting Grant . It will run for two years , with a possible extension of up to two additional years . The work will take place at NEO in Flemingsberg , within Karolinska Institutet, in an international and interdisciplinary environment with access to state-of-the-art core facilities including cell sorting, microscopy, sequencing, mouse facilities, and clinical samples. The research will use hematopoietic stem cells from mice to identify metabolic drivers of stem cell aging. Methods include flow cytometry, RNA/DNA sequencing, proteomics, metabolomics, immunofluorescence microscopy, HSC transplantation , and assays across multiple organs. The broader aim is to understand how rejuvenating the blood system may influence systemic metabolism during aging and to explore ways to restore cellular function and extend healthspan. Applicants should have a PhD in hematology, hematopoietic stem cell biology, aging biology, or a closely related area, plus at least one first-author publication in a recognized peer-reviewed journal. Strong experience with mice and Laboratory Animal Science certification are required, together with excellent English, strong analytical skills, familiarity with data analysis tools, and a collaborative, highly motivated research mindset. Experience with advanced flow cytometry, experimental stem cell biology, hematology, R, and statistics is especially desirable. Applications must be submitted through the Varbi recruitment system by 2026-08-27 . The application should include a complete CV in English, a short publication list, positions held, awards and prizes, and a Google Scholar profile link . The university asks applicants not to apply by email.