Jiří Vrba

Lékařská Fakulta Univerzita Palackého v Olomouci

Czech Republic

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Articles (14)

Year:

2025

Year:

2024

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2023

Year:

2023

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2022

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2022

We report the synthesis and testing of a novel type (new lead structure) of powerful and highly selective human O-N -acetyl-β- d -glucosaminidase (enzyme associated with Alzheimer's disease) inhibitors that are not based on transition state mimetics.

Year:

2022

Year:

2021

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2021

Year:

2021

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2020

Year:

2020

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2020

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2020

Collaborators (13)

Dinko Mitrečić

CROATIA

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Patrick Weber

Graz University of Technology

AUSTRIA

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Martin Modriansky

professor

Palacký University, Olomouc

CZECH REPUBLIC

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Alena Rajnochová Svobodová

associate professor

Palacký University, Olomouc

CZECH REPUBLIC

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Jiri Pospisil

Associated professor of phytochemistry and natural product chemistry

Univerzita Palackého v Olomouci

CZECH REPUBLIC

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Krzysztof Stolarczyk

lecturer

University of Warsaw

POLAND

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Kateřina Valentová

Head of the Laboratory

Institute of Microbiology

CZECH REPUBLIC

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Katerina Cizkova

Associate Professor

Palacký University, Olomouc

CZECH REPUBLIC

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Pavel Kosina

Assistant professor

Palacký University, Olomouc

CZECH REPUBLIC

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Barbora Papoušková

Přírodovědecká Fakulta, Univerzita Karlova

CZECH REPUBLIC

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Arnold E. Stütz

Graz University of Technology

AUSTRIA

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Freija De Vleeschouwer

Vrije Universiteit Brussel

BELGIUM

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Damian Dziubak

University of Warsaw

POLAND

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Jiří Vrba

Research Interests

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Articles (14)

Lipid membrane behavior of nitro-fatty acids and their loading into liposomes to activate Nrf2 pathway in RAW264.7 cells with impact on intracellular NO production

Phytocannabinoids and gingival inflammation: Preclinical findings and a placebo-controlled double-blind randomized clinical trial with cannabidiol

Hepatic biotransformation of non-psychotropic phytocannabinoids and activity screening on cytochromes P450 and UDP-glucuronosyltransferases

Metabolic profiling of silymarin constituents in urine and feces of healthy volunteers: A 90-day study

Diaminocyclopentane-derived O-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease

Effect of the flavonoids quercetin and taxifolin on UVA-induced damage to human primary skin keratinocytes and fibroblasts

Diaminocyclopentane-derived <i>O</i>-GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease

Cysteamine assay for the evaluation of bioactive electrophiles

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases

Cubosomal lipid formulation of nitroalkene fatty acids: Preparation, stability and biological effects

Diferulate: A highly effective electron donor

Effect of UVA radiation on the Nrf2 signalling pathway in human skin cells

Identification of UDP-glucuronosyltransferases involved in the metabolism of silymarin flavonolignans

Identification of human sulfotransferases active towards silymarin flavonolignans and taxifolin

Collaborators (13)

Dinko Mitrečić

Patrick Weber

Martin Modriansky

Alena Rajnochová Svobodová

Jiri Pospisil

Krzysztof Stolarczyk

Kateřina Valentová

Katerina Cizkova

Pavel Kosina

Barbora Papoušková

Arnold E. Stütz

Freija De Vleeschouwer

Damian Dziubak

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