Jia Lu

The rupture of intracranial aneurysms (IAs) is a complicated phenomenon of which the mechanism is not fully understood. The purpose of this study is to associate local solid mechanical, hemodynamic, and morphological characteristics with rupture regions through statistical means, in an attempt to identify the parameters that are indicative of rupture propensity for IAs. Twenty patient‐specific ruptured IA models were reconstructed from digital subtraction angiography (DSA), and applied in the analysis of wall tension, wall shear stress (WSS) and curvature. The precise rupture locations were marked out through intraoperative videos. Pearson correlation analysis was employed to investigate the correlations of these three parameters with patient characteristics and global geometric features. Univariate and multivariate logistic regression analysis were further performed on wall tension, WSS and curvature with regards to rupture and nonrupture regions. Receiver operating characteristic (ROC) analysis defining area under the curve (AUC) was performed on these three parameters. The univariate model of wall tension (AUC, 0.9750), WSS (AUC, 0.9300), curvature (0.8150) and their combined multivariate model (AUC, 0.9875) all present high AUC values. The wall tension, WSS and curvature are acceptable parameters relating to rupture regions. The rupture odd is more sensitive to the wall tension and WSS than curvature. Each logistic model is capable in discriminating ruptures from nonrupture regions, while the multivariate model is the most efficient.

Simulation‐based studies of the cardiovascular structure such as aorta have become increasingly popular for many biomedical problems such as predictions of aneurysm rupture. A critical step in these simulations is the development of constitutive models that accurately describe the tissue's mechanical behavior. In this work, we present a new constitutive model, which explicitly accounts for the gradual recruitment of collagen fibers. The recruitment is considered using an effective stretch, which is a continuum‐scale kinematic variable measuring the uncrimped stretch of the tissue in an average sense. The strain energy of a fiber bundle is described by a quadratic function of the effective strain. Constitutive models formulated in this manner are applied to describe the responses of ascending thoracic aortic aneurysm and porcine thoracic aorta tissues. The heterogeneous properties of the ATAA tissue are extracted from bulge inflation test data, and then used in finite element analysis to simulate the inflation test. The descriptive and predictive capabilities are further assessed using planar testing data of porcine thoracic aortic tissues. It is found that the constitutive model can accurately describe the stress–strain relations. In particular, the finite element simulation replicates the displacement, strain, and stress distributions with excellent fidelity.