Jian-Ke Tie

United States

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Articles (12)

Year:

2025

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2025

Year:

2025

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2025

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2024

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2023

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2023

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2023

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2021

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2021

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2021

Year:

2020

Collaborators (4)

Lars Pedersen

National Institute of Environmental Health Sciences

UNITED STATES

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Craig Williams

Lecturer to Professor

University of Queensland

AUSTRALIA

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Yoshitomo Suhara

Shibaura Institute of Technology

JAPAN

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Nadia Elghobashi-Meinhardt

Assistant Professor

University College Dublin

IRELAND

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Jian-Ke Tie

Research Interests

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Articles (12)

Structural and functional insights into γ-glutamyl carboxylase-factor IX interaction: implications for vitamin K-dependent bleeding disorders

Molecular insights into the comorbidity of vitamin K-dependent clotting factor deficiency and chondrodysplasia punctata

<i>In Silico</i> and <i>In Vitro</i> Studies of Potential Novel Vitamin K Epoxide Reductase (VKOR) Inhibitors Suggest an Updated Structure–Activity Relationship

Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase

Multimodal mechanisms of pathogenic variants in the signal peptide of FIX leading to hemophilia B.

A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase

Molecular basis of inherited protein C deficiency results from genetic variations in the signal peptide and propeptide regions.

Synthesis of new vitamin K derivatives with a ketone group at the C-1′ position of the side chain and their conversion to menaquinone-4

Naturally occurring UBIAD1 mutations differentially affect menaquinone biosynthesis and vitamin K-dependent carboxylation.

A novel vitamin K derived anticoagulant tolerant to genetic variations of vitamin K epoxide reductase.

γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

Collaborators (4)

Lars Pedersen

Craig Williams

Yoshitomo Suhara

Nadia Elghobashi-Meinhardt

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