Jianjun Chen

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Chair/Professor

Beckman Research Institute, City of Hope

United States

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About

Jianjun Chen is a Chair/Professor at the City of Hope Beckman Research Institute in the United States. His research focuses on acute myeloid leukemia (AML), with recent articles exploring topics such as ribosome biogenesis, oncogenic transcription programs, and crosstalk between RNA modifications and mitochondrial metabolism. He investigates the role of various molecules and pathways in the treatment and understanding of leukemia and cancer immunology.

Recent Grants

Grant: Close

The role and mechanism of FTO in leukemogenesis and drug response

Open Date: 2017-04-01

Close Date: 2022-03-31

Grant: Close

Targeting TET1 signaling to treat acute myeloid leukemia

Open Date: 2017-01-01

Close Date: 2021-12-31

Grant: Close

The role and functional mechanism of TET1 in MLL-rearranged leukemia

Open Date: 2014-04-01

Close Date: 2019-03-31

Grant: Close

Potential therapeutic implications of targeting miR-150 in acute myeloid leukemia

Open Date: 2014-01-01

Close Date: 2018-12-31

Grant: Close

The role and functional mechanism of a miRNA cluster, mir-17-92 in leukemogenesis

Open Date: 2008-06-01

Close Date: 2014-04-30

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2023

Collaborators (5)

Jianhua Yu

Professor

City Of Hope National Medical Center

UNITED STATES

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Vu Ngo

Beckman Research Institute, City of Hope

UNITED STATES

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Chuan He

University of Chicago

UNITED STATES

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Tasha Barr

Beckman Research Institute, City of Hope

UNITED STATES

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Yuan Che

Beckman Research Institute, City of Hope

UNITED STATES

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Jianjun Chen

Research Interests

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Recent Grants

Articles (20)

FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia

PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1

Targeting RNA Modification and Mitochondrial Metabolism Crosstalk in Leukemic Stem Cells with CDK7 Inhibitor TGN-1062

Nuclear Control of Mitochondrial Homeostasis and Venetoclax Efficacy in AML via COX4I1

YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies.

NAT10-mediated mRNA N4-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia

YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunity.

IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells.

Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling.

Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification

The roles and therapeutic implications of messenger RNA internal N7‐methylguanosine and N6‐methyladenosine modifications in chemoresistance

The roles and implications of RNA m6A modification in cancer

A homozygous nonsense mutation in DNAJC30 causes Leber's hereditary optic neuropathy with Leigh-like phenotypes

METTL3-Mediated m6A Modification Controls Splicing Factor Abundance and Contributes to Aggressive CLL.

N6-methyladenosine-mediated gene regulation and therapeutic implications.

RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators.

Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia.

Targeting fat mass and obesity-associated protein mitigates human colorectal cancer growth <i>in vitro</i> and in a murine model.

YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8<sup>+</sup> T cells.

METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.

Collaborators (5)

Jianhua Yu

Vu Ngo

Chuan He

Tasha Barr

Yuan Che

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