Jill Smith

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Georgetown University School of Medicine

United States

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About

Jill Smith is a Professor at Georgetown University School of Medicine, based in the United States. Her research primarily focuses on the role of cholecystokinin receptors and immune response in cancer therapies, particularly hepatocellular carcinoma and pancreatic cancer. Recent publications include studies on proglumide's impact on immune efficacy and novel therapeutic strategies for pancreatic carcinogenesis.

Recent Grants

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High fat diet stimulates pancreatic cancer through the actions of Cholecystokinin

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Novel Nanoparticle Therapy for Pancreatic Cancer

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Pancreatic cyst fluid reference set; this is a multicenter trial to collect fluid from subjects undergoing endoscopy or surgery for pancreatic cysts and to develop a Biorepository for future research.

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miRNAs, regulators of gastrin-CCKR pathway and novel therapeutic targets in pancreatic carcinogenesis.

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Pancreatic Cancer Research

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Articles (14)

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2025

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2025

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2025

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2020

Collaborators (4)

Amrita Cheema

Professor

Georgetown University

UNITED STATES

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Aiwu He

Associate Professor

Georgetown University

UNITED STATES

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Hong-Bin Fang

Associate Professor

Georgetown University Medical Center

UNITED STATES

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Sivanesan Dakshanamurthy

Georgetown University Medical Center

UNITED STATES

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Jill Smith

Research Interests

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About

Recent Grants

Articles (14)

Mechanistic Insights into Proglumide’s Role in Immune Cell Efficacy and Response to Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma

Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer

Endogenous Alcohol and Auto-Brewery Syndrome Complicating Liver Transplantation: A Case Report and Literature Review

The Role of a Cholecystokinin Receptor Antagonist in the Management of Chronic Pancreatitis: A Phase 1 Trial

Implicating the cholecystokinin B receptor in liver stem cell oncogenesis

Cholecystokinin Receptor Antagonist Induces Pancreatic Stellate Cell Plasticity Rendering the Tumor Microenvironment Less Oncogenic

Treatment with a Cholecystokinin Receptor Antagonist, Proglumide, Improves Efficacy of Immune Checkpoint Antibodies in Hepatocellular Carcinoma

Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression

Safety and Pharmacokinetic Assessment of Oral Proglumide in Those with Hepatic Impairment

Proglumide Reverses Nonalcoholic Steatohepatitis by Interaction with the Farnesoid X Receptor and Altering the Microbiome

TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC

Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas

Cholecystokinin Receptor Antagonist Improves Efficacy of Chemotherapy in Murine Models of Pancreatic Cancer by Altering the Tumor Microenvironment

Cholecystokinin Receptor Antagonist Therapy Decreases Inflammation and Fibrosis in Chronic Pancreatitis

Collaborators (4)

Amrita Cheema

Aiwu He

Hong-Bin Fang

Sivanesan Dakshanamurthy

Make your next move.

Jill Smith

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (14)

Mechanistic Insights into Proglumide’s Role in Immune Cell Efficacy and Response to Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma

Target-Specific Locked Nucleic Acid Gapmer Decreases Growth and Metastases of Pancreatic Cancer

Endogenous Alcohol and Auto-Brewery Syndrome Complicating Liver Transplantation: A Case Report and Literature Review

The Role of a Cholecystokinin Receptor Antagonist in the Management of Chronic Pancreatitis: A Phase 1 Trial

Implicating the cholecystokinin B receptor in liver stem cell oncogenesis

Cholecystokinin Receptor Antagonist Induces Pancreatic Stellate Cell Plasticity Rendering the Tumor Microenvironment Less Oncogenic

Treatment with a Cholecystokinin Receptor Antagonist, Proglumide, Improves Efficacy of Immune Checkpoint Antibodies in Hepatocellular Carcinoma

Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression

Safety and Pharmacokinetic Assessment of Oral Proglumide in Those with Hepatic Impairment

Proglumide Reverses Nonalcoholic Steatohepatitis by Interaction with the Farnesoid X Receptor and Altering the Microbiome

TGF&beta; Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGF&beta; Induced EMT in PDAC

Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas

Cholecystokinin Receptor Antagonist Improves Efficacy of Chemotherapy in Murine Models of Pancreatic Cancer by Altering the Tumor Microenvironment

Cholecystokinin Receptor Antagonist Therapy Decreases Inflammation and Fibrosis in Chronic Pancreatitis

Collaborators (4)

Amrita Cheema

Aiwu He

Hong-Bin Fang

Sivanesan Dakshanamurthy

Make your next move.

TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC