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Jiyang Yu

Has grant

Interim Chair

St. Jude Children's Research Hospital

United States

Research Interests

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Recent Grants

Grant: Open

Identification of NEK5 as a Hidden Driver in Kidney Cancer

Open Date: 2025-11-01

Close Date: 2029-10-31

Grant: Close

Evaluation of relatlimab in MYC-driven pediatric brain tumors

Open Date: 2025-03-01

Close Date: 2026-02-01

Grant: Open

Dissecting high-risk cell states in neuroblastoma

Open Date: 2024-03-01

Close Date: 2029-02-01

Grant: Open

Investigating the molecular determinants driving response and resistance to HDAC6 targeted therapy in breast cancer

Open Date: 2024-03-01

Close Date: 2029-02-01

Grant: Open

Enabling immunotherapy for high-risk Group 3 medulloblastoma via systems immunology

Open Date: 2023-09-01

Close Date: 2028-08-01

Articles (20)

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Collaborators (10)

George Mias

Associate Professor with Tenure

Michigan State University

UNITED STATES

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Mignon L. Loh

Professor

University of Washington

UNITED STATES

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Yehuda G Assaraf

Head of the Fred Wyszkowski Cancer Research Laboratory

Technion - Israel Institute of Technology

ISRAEL

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Akhilesh Mishra

Assistant Professor

National Institute of Technology Rourkela

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Charles Gawad

Stanford University School of Medicine

UNITED STATES

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Sofia Bentivegna

University of Copenhagen

DENMARK

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Jakob Schmidt Jespersen

Staff scientist

Københavns Universitet

DENMARK

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Evan Glazer

Assistant Professor

University of Tennessee Health Science Center College of Medicine Memphis

UNITED STATES

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Catherine E Welsh

Associate Professor

Hope College

UNITED STATES

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Hasan Alniss

Associate Professor of Medicinal Chemistry

university of sharjah

UNITED ARAB EMIRATES

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Jiyang Yu

Research Interests

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Recent Grants

Articles (20)

SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mice

Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells

HKDC1 promotes liver cancer stemness under hypoxia through stabilizing β-catenin

DNTT-mediated DNA damage response drives inotuzumab ozogamicin resistance in B-cell acute lymphoblastic leukemia

Molecular and pharmacological heterogeneity of ETV6::RUNX1 acute lymphoblastic leukemia

Latent epigenetic programs in Müller glia contribute to stress and disease response in the retina

TEAD switches interacting partners along neural progenitor lineage progression to execute distinct functions

Differentiation-dependent EBF1 activity determines CD22 transcription and leukemia sensitivity to inotuzumab ozogamicin

scMINER: a mutual information-based framework for clustering and hidden driver inference from single-cell transcriptomics data

GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR T-cell Resistance via Macrophage Remodeling

Spotiphy enables single-cell spatial whole transcriptomics across the entire section

Protocol for predicting the single-cell network-based gene activity landscape during human B cell development

Antileukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 in acute lymphoblastic leukemia preclinical models.

Transcriptome size matters for single-cell RNA-seq normalization and bulk deconvolution

Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL.

Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy

Folylpolyglutamate synthetase inactivation in relapsed ALL induces a druggable folate metabolic vulnerability.

Preclinical development of lentiviral vector gene therapy for Diamond-Blackfan anemia syndrome.

Impact of Age on Pharmacogenomics and Treatment Outcomes of B-Cell Acute Lymphoblastic Leukemia

T cell dysfunction and therapeutic intervention in cancer.

Collaborators (10)

George Mias

Mignon L. Loh

Yehuda G Assaraf

Akhilesh Mishra

Charles Gawad

Sofia Bentivegna

Jakob Schmidt Jespersen

Evan Glazer

Catherine E Welsh

Hasan Alniss

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