Joana Bicker

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Invited Assistant Professor

Faculty of Pharmacy, University of Lisbon

Portugal

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About

Joana Bicker is an Invited Assistant Professor at the Faculty of Pharmacy of the University of Coimbra, Portugal. Her research areas encompass chronopharmacokinetics, neurodegeneration, and pharmacokinetics of various compounds, as evidenced by her recent articles on the antidepressant paroxetine and neuroprotective effects of irbesartan. Additionally, she explores mechanisms of rapid-acting antidepressants and pharmacokinetics in patients with refractory epilepsy.

Recent Grants

Grant: Close

EpiMod: Epigenetic modulation of blood-brain barrier integrity for the prevention of epileptogenesis (Principal Investigator)

Open Date: 2023-03-01

Close Date:

Grant: Close

Prenatal tryptophan as a key player in gut-brain axis dysfunction: an autism spectrum disorder preclinical approach (Team Member)

Open Date: 2023-01-01

Close Date:

Grant: Close

MitoBOOST v2.0: Proof of Concept for the Use of Mitochondria-Targeted Polyphenols to Treat Non-Alcoholic Fatty Liver Disease (Team Member)

Open Date: 2022-10-01

Close Date:

Grant: Close

4Epilepsy - Promoting the quality-of-life of epileptic patients through personalized medicine (Contracted Researcher)

Open Date: 2019-01-01

Close Date: 2021-01-01

Grant: Close

N2BD - Development of a Novel Nose-to-Brain Multifunctional Nanoplatform for the Treatment of Depression and Prevention of Pharmacoresistance Development (Team Member)

Open Date: 2018-01-01

Close Date: 2021-01-01

Joana Bicker

Research Interests

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About

Recent Grants

Articles (20)

Chronopharmacokinetics of the antidepressant paroxetine: An in vitro and in vivo approach

New low-dose curcumin derivative with therapeutic potential in Alzheimer’s disease: Results from an in vitro and in vivo study in mice

Protective effects of irbesartan against neurodegeneration in APP/PS1 mice: Unraveling its triple anti-apoptotic, anti-inflammatory and anti-oxidant action

Novel mechanisms underlying rapid-acting antidepressants: ketamine-like compounds, neurosteroid GABAkines, and psychedelics

A new population pharmacokinetic model for dosing optimization of zonisamide in patients with refractory epilepsy

Pharmacokinetics of Non-Psychotropic Phytocannabinoids

Population pharmacokinetics of levetiracetam in patients diagnosed with refractory epilepsy: A real‐world study

Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

Unveiling the potential of intranasal delivery of renin-angiotensin system drugs: Insights on the pharmacokinetics of irbesartan

Synthesis of a dehydrodieugenol B derivative as a lead compound for visceral leishmaniasis—mechanism of action and <i>in vivo</i> pharmacokinetic studies

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment

Nasal-PAMPA: A novel non-cell-based high throughput screening assay for prediction of nasal drug permeability

Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy

Therapeutic Drug Monitoring of Amikacin in Neutropenic Oncology Patients

Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients

Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation

Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression

Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications.

HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring.

Is intranasal administration an opportunity for direct brain delivery of lacosamide?

Collaborators (9)

Elena Sánchez-López

Robert Dallmann

Amanda Cano

Miren Ettcheto

Amílcar Falcão

Sónia Silva

Anabela M. Almeida

Ana Fortuna

Jordi Olloquequi

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